keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Hydroxystilbamidine ((E)-hydroxystilbamidine) 是一种能够结合 DNA 和 RNA 的染料, 也被发现是细胞核糖核酸酶的强效抑制剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,290 | 现货 | ||
2 mg | ¥ 1,930 | 现货 | ||
5 mg | ¥ 2,990 | 现货 | ||
10 mg | ¥ 4,390 | 现货 | ||
25 mg | ¥ 6,910 | 现货 | ||
50 mg | ¥ 9,480 | 现货 | ||
100 mg | ¥ 12,800 | 现货 | ||
500 mg | ¥ 25,600 | 现货 |
产品描述 | Hydroxystilbamidine ((E)-hydroxystilbamidine), a dye capable of binding to both DNA and RNA, has been found to be a powerful inhibitor of cellular ribonucleases. |
体外活性 | Hydroxystilbamidine permits the recovery of mRNA after polysome released with Nonidet P-40 (NP-40). Sucrose gradient analysis of detergent-lysed postnuclear supernates is used to analyze the size distribution of NP-40-released polysomes. The heparin gradient shows some polyribosomes, whereas the Hydroxystilbamidine gradient shows a remarkably large peak of very heavy polyribosomes. This peak is obtained reproducibly if Hydroxystilbamidine is present before the addition of NP-40[1]. |
体内活性 | Hydroxystilbamidine is an effective suppressor of the plaque-forming cell (PFC) response when given before sheep erythrocytes (SRBC) stimulation. Hydroxystilbamidine depresses the plaque response of the treated mice. Fewer PFC are observed in Hydroxystilbamidine-treated mice throughout the experiment, but the level of suppression decreases with time. By day 14, the number of PFC observed in both the Hydroxystilbamidine treated mice and the control group is essentially at the background level[2]. |
别名 | Oxistilbamidinum, 羟芪巴脒, (E)-hydroxystilbamidine, 2-Hydroxy-4,4'-diguanylstilbene, Bis(8-hydroxyquinolinium) sulphate |
分子量 | 280.32 |
分子式 | C16H16N4O |
CAS No. | 495-99-8 |
keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Insoluble
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Hydroxystilbamidine 495-99-8 Others Oxistilbamidinum 羟芪巴脒 (E)-hydroxystilbamidine 2-Hydroxy-4,4'-diguanylstilbene Bis(8-hydroxyquinolinium) sulphate Inhibitor inhibitor inhibit