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Tegafur

Name: Tegafur
Brand: TargetMol
SKU: T1378
Price: 148 CNY
Availability: InStock
Rating: 5 (10 reviews)

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纯度: 99.89%

货号 T1378Cas号 17902-23-7

别名 替加氟, NSC 148958, FT-207, FT 207, Fluorafur

Tegafur (FT 207) 是一种前药，在肝脏中被细胞色素 P-450 酶逐渐转化为氟尿嘧啶。它是抗代谢物氟尿嘧啶的同源物，具有抗肿瘤活性。

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Tegafur

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很棒

纯度: 99.89%

货号 T1378 别名 替加氟, NSC 148958, FT-207, FT 207, FluorafurCas号 17902-23-7

Tegafur (FT 207) 是一种前药，在肝脏中被细胞色素 P-450 酶逐渐转化为氟尿嘧啶。它是抗代谢物氟尿嘧啶的同源物，具有抗肿瘤活性。

规格	价格	库存
10 mg	¥ 148	现货
25 mg	¥ 218	现货
50 mg	¥ 297	现货
100 mg	¥ 432	现货
500 mg	¥ 835	现货
1 g	¥ 1,220	现货
1 mL x 10 mM (in DMSO)	¥ 195	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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COA HNMR HPLC 产品操作手册

产品介绍

Tegafur AI Summary

Tegafur exhibits a wide range of bioactivities, notably its significant antitumor effects across various cancer cell lines and models. It prolongs survival in mice bearing lymphocytic leukemia and inhibits tumor growth in both in vivo and in vitro settings. Specifically, it shows dose-dependent cytotoxicity against L1210 cells and exhibits inhibition percentages in human A549 and Ec9706 cells. The compound also demonstrates efficacy against human LS1034, HT29, BXPC3, SK-ES, Pan02, and U251 cells, as well as mouse CT26 cells, with observed changes in histone acetylation levels indicating HDAC inhibition. Tegafur has also shown antibacterial and antifungal activities, with specific activity against Staphylococcus aureus, Escherichia coli, and Candida albicans, among others. Furthermore, it inhibits the SARS-CoV-2 3CL-Pro protease and shows some antiviral action against SARS-CoV-2, although with moderate efficacy. The compound has been tested for its effects on biomarkers related to metabolic and organ function, including glucose levels, ALP, AST activity, and bilirubin concentration, suggesting broad systemic effects. It also exhibits liver toxicities, including moderate to severe liver damage, cirrhosis, and hepatitis, and affects body weight in animal models. Despite its broad bioactivity spectrum, the compound shows limited brain penetration and specific partition coefficients, indicating varying affinity to different tissues and environments. Overall, Tegafur presents as a multi-faceted bioactive agent with substantial potential for antitumor and antimicrobial applications, albeit with associated toxicity considerations..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Tegafur (FT 207) is a congener of the antimetabolite fluorouracil with antineoplastic activity. Tegafur is a prodrug that is gradually converted to fluorouracil in the liver by the cytochrome P-450 enzyme.
别名	替加氟, NSC 148958, FT-207, FT 207, Fluorafur

化学信息

分子量	200.17
分子式	C₈H₉FN₂O₃
CAS No.	17902-23-7
Smiles	O=C1N(C=C(F)C(=O)N1)C2CCCO2
密度	1.3222 g/cm3 (Estimated)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (249.79 mM), Sonication is recommended.

Ethanol: 7 mg/mL (34.97 mM), Sonication is recommended.

H2O: 8 mg/mL (39.97 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.99 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

Ethanol/H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.9958 mL	24.9788 mL	49.9575 mL	249.7877 mL
5 mM	0.9992 mL	4.9958 mL	9.9915 mL	49.9575 mL
10 mM	0.4996 mL	2.4979 mL	4.9958 mL	24.9788 mL
20 mM	0.2498 mL	1.2489 mL	2.4979 mL	12.4894 mL