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顶部相关产品产品介绍化学信息储存和溶解信息计算器

Cinoxacin

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纯度: 99.98%

货号 T0274Cas号 28657-80-9

别名 西诺沙星, Compound 64716

Cinoxacin (Compound 64716) 是一种喹诺酮类的合成抗生素, 与Oxolinic acid 和 Nalidixic acid 活性相似。

Cinoxacin
其他形式的 “Cinoxacin”:
Cinoxacin (Standard)TMSM-075628657-80-9
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Cinoxacin

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Rating icon 很棒

纯度: 99.98%

货号 T0274 别名 西诺沙星, Compound 64716Cas号 28657-80-9

Cinoxacin (Compound 64716) 是一种喹诺酮类的合成抗生素, 与Oxolinic acid 和 Nalidixic acid 活性相似。

规格价格库存数量
10 mg
¥ 128
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25 mg
¥ 193
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50 mg
¥ 269
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100 mg
¥ 426
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1 mL x 10 mM (in DMSO)
¥ 195
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产品介绍

Cinoxacin AI Summary
Cinoxacin exhibits multifaceted bioactivities across various biological targets and organism models. It demonstrates inhibitory activity at low concentrations against enzymes such as beta-lactamase, chymotrypsin, and malate dehydrogenase (MDH), with all inhibition levels below 5.0%. The compound also inhibits DNA gyrase-induced DNA cleavage with a MIC of 43.0 µg/mL and shows antibacterial activities against several strains of Escherichia coli, Klebsiella pneumonia, and Pseudomonas aeruginosa with MIC values ranging from 1.6 µg/mL to >100.0 µg/mL. Additionally, it inhibits human FAAH at 1 µM with an inhibition rate of 3.36%. In antiplasmodial assays, Cinoxacin shows moderate potency against Plasmodium falciparum strains 3D7, HB3, and W2. It also exhibits inhibition of Plasmodium falciparum lines Dd2, GB4, 7G8, showing IC50 values ranging from 5633.4 nM to 10000.0 nM. Other notable activities include modulation of Lamin A splicing (5.0 nM), inhibition of Human Jumonji Domain Containing 2E (JMJD2E), and action against malaria parasite plastids and several enzymes such as Bloom's syndrome helicase (BLM) and ALDH1A1. Cinoxacin affects liver enzyme functions, increasing levels of alkaline phosphatase, SGOT, SGPT, LDH, and GGT, indicating potential impacts on liver function. However, it shows no significant bioactivity associated with drug-induced liver injury (DILI), receiving a score of 0.0 in related assays. The compound's pKa of 4.7 suggests significant ionization under physiological pH conditions, affecting its bioavailability and interactions. In transporter assays, Cinoxacin strongly inhibits the uptake of sodium fluorescein in OATP1B1- and OATP1B3-transfected CHO cells. While it has shown moderate liver toxicity in clinical trials, it exhibits high intrinsic clearance in human liver microsomes, with a clearance rate of less than 3.0 mL/min/g. Against SARS-CoV-2, Cinoxacin demonstrated inhibition of viral-induced cytotoxicity in VERO-6 cells and moderate inhibition of the viral 3CL-Pro protease. However, its overall antiviral potency against SARS-CoV-2 was relatively weak with an IC50 value exceeding 20000.0 nM in specific assays. Lastly, the compound shows varied bioactivities against human HDAC6 and exhibits potential as an antimalarial agent, inhibiting both hepatic and blood stages of malaria parasites, including Plasmodium yoelii yoelii 265 BY and chloroquine-sensitive P. falciparum, with IC50 values ranging from 28.5 µg/mL to 118.2 µg/mL. In summary, Cinoxacin displays a diverse array of biochemical activities, potential therapeutic implications, and moderate levels of toxicity in various biological contexts..
Note: Summary generated by AI. Data source: ChEMBL
生物活性
产品描述
Cinoxacin (Compound 64716), an older synthetic antimicrobial, was related to the quinolone class of antibiotics. Its activity was similar to oxolinic acid and nalidixic acid.
别名西诺沙星, Compound 64716
化学信息
分子量262.22
分子式C12H10N2O5
CAS No.28657-80-9
SmilesCCn1nc(C(O)=O)c(=O)c2cc3OCOc3cc12
密度1.64g/cm3
颜色White
物理性状Solid
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
溶解度信息
DMSO: 4.55 mg/mL (17.35 mM), Sonication is recommended.
溶液配制表
DMSO
1mg5mg10mg50mg
1 mM3.8136 mL19.0680 mL38.1359 mL190.6796 mL
5 mM0.7627 mL3.8136 mL7.6272 mL38.1359 mL
10 mM0.3814 mL1.9068 mL3.8136 mL19.0680 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
TargetMol | Animal experiments 比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments 一共给药动物10只，您使用的配方为5%TargetMol | reagent DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为2mg/mL。
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent （ 母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法: 取 50μLDMSOTargetMol | reagent 母液，添加 300 μLPEG300TargetMol | reagent 混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline/PBS/ddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ， 玉米油 等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

urinary tract infectionsTopo IIInhibitorinhibitGram-negative aerobic bacteriaDNA/RNA SynthesisCompound-64716Compound64716CinoxacinBacterialantibioticsAntibioticantibacterial agent
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