Name: CAY10594
Brand: TargetMol
SKU: T7280
Price: 628 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 628

现货

5 mg

¥ 1,230

现货

10 mg

¥ 1,980

现货

25 mg

¥ 3,370

现货

50 mg

¥ 4,890

现货

100 mg

¥ 6,860

现货

200 mg

¥ 9,280

现货

1 mL x 10 mM (in DMSO)

¥ 1,180

现货

产品介绍

生物活性

产品描述	CAY10594 is a potent phospholipase D2(PLD2) inhibitor. CAY10594 ameliorates acetaminophen-induced acute liver injury by regulating the phosphorylated-GSK-3β/JNK axis.
体内活性	CAY10594的给药显著以剂量依赖的方式阻断了急性肝损伤，8mg/kg的CAY10594几乎完全抑制了损伤。在急性肝损伤的病理进程中，GSH水平降低，而CAY10594在APAP挑战后6小时给药显著恢复了这一点。GSK-3β (Serine 9)/JNK的磷酸化主要参与APAP引起的肝损伤。CAY10594给药强烈阻断了APAP诱导的急性肝损伤模型中的GSK-3β (Serine 9)/JNK磷酸化。一致地，CAY10594处理的小鼠中，肝细胞的细胞质和线粒体中持续的JNK激活也有所减少。多种类型的免疫细胞也涉及APAP引起的肝损伤。然而，与APAP挑战的车辆处理组和CAY10594处理组的小鼠相比，中性粒细胞和单核细胞群体没有差异。CAY10594的治疗性给药也显著减轻了APAP挑战引起的肝损害，提高了生存率[1]。
动物实验	Mice were fasted for 16?hours before APAP injection. APAP (500?mg/kg) was administered with oral gavage in mice. CAY10594 (N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4,5]dec-8-yl)ethyl]-2-naphthalene carboxamide)23 was dissolved in 1% DMSO and intraperitoneally administered to mice 30?minutes prior to APAP injection for examining protective effects or after 3?hours from APAP challenge for investigating therapeutic effects of CAY10594[1].

化学信息

分子量	428.53
分子式	C₂₆H₂₈N₄O₂
CAS No.	1130067-34-3
Smiles	O=C(NCCN1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccc2ccccc2c1
密度	1.29 g/cm3 (Predicted)
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 20 mg/mL (46.67 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.33 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

体内实验配液计算器