购物车

您的购物车当前为空

Tetrahydrozoline

Name: Tetrahydrozoline
Brand: TargetMol
SKU: T0397
Price: 113 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.77%

货号 T0397Cas号 84-22-0

别名 四氢唑啉, 四氢唑林, Tetryzoline, Tetryzolin

Tetrahydrozoline (Tetryzoline) 是一种咪唑啉的衍生物，是一种 α-肾上腺素能 (α-adrenergic) 激动剂，能引起血管收缩，广泛用于研究鼻充血、结膜充血。

Tetrahydrozoline

一键复制产品信息

很棒

纯度: 99.77%

货号 T0397 别名 四氢唑啉, 四氢唑林, Tetryzoline, TetryzolinCas号 84-22-0

Tetrahydrozoline (Tetryzoline) 是一种咪唑啉的衍生物，是一种 α-肾上腺素能 (α-adrenergic) 激动剂，能引起血管收缩，广泛用于研究鼻充血、结膜充血。

规格	价格	库存
5 mg	¥ 113	现货
10 mg	¥ 155	现货
25 mg	¥ 248	现货
50 mg	¥ 353	现货
100 mg	¥ 529	现货
500 mg	¥ 1,300	现货
1 mL x 10 mM (in DMSO)	¥ 119	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.77%

颜色: 白色

性状: Solid

联系我们获取更多批次信息

资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

Tetrahydrozoline AI Summary

Tetrahydrozoline exhibits a range of bioactivities across different biological systems. It demonstrates central hypotensive activity with a 25% decrease in arterial pressure in anesthetized normotensive rats and induces hypertensive activity with a 60 mmHg increase in pithed rats. The compound has a partition coefficient (LogD) of -0.9 in octanol/buffer at pH 7.4 and shows binding affinities to alpha-1 and alpha-2 adrenergic receptors, with IC50 values of 1600.0 nM and 30.0 nM, respectively. It also interacts with the alpha-adrenergic receptors in the rabbit jejunum and rat brain. Moreover, Tetrahydrozoline has shown various receptor and enzyme activities, including: - Potentiation of the human D1 dopamine receptor at 2592.8 nM. - Inhibition of mammalian selenoprotein thioredoxin reductase 1 at 14125.4 nM. - Inhibition of regulator of G protein signaling 4 at 29.9 nM. - Enhancement of Arylsulfatase A at 756.9 nM. In antiviral research, it inhibits SARS-CoV-2 induced cytotoxicity of VERO-6 cells with modest efficacy (IC50 > 19952.62 nM) and shows 17.25% inhibition against SARS-CoV-2 3CL-Pro protease at 20 µM. The compound also displayed varied inhibition rates against the human HDAC6 enzyme, suggesting inhibitory activity. The compound further displays binding affinities for human ADRA2A, HTR1A, OPRM1, and ADRA1A receptors, with notable agonist activity at human ADRA1A (AC50 of 6.1 nM). For other evaluated targets, significant activity was not observed (AC50 > 30000.0 nM). Tetrahydrozoline is noted for its absence of hepatic side effects according to the Drug Induced Liver Injury Prediction System (DILIps) training set, confirming a safe hepatic profile. Its basic pKa value is determined to be 10.6, indicating its behavior in biological environments. These diverse bioactivities highlight its significance for further pharmacological and antiviral studies..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Tetrahydrozoline (Tetryzoline), an alpha agonist, have an effect on the constriction of conjunctival blood vessels. This contributes to relieve the redness of the eye resulted from minor ocular irritants.
别名	四氢唑啉, 四氢唑林, Tetryzoline, Tetryzolin

化学信息

分子量	200.28
分子式	C₁₃H₁₆N₂
CAS No.	84-22-0
Smiles	C1CN=C(N1)C1CCCc2ccccc12
密度	1.2 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 45 mg/mL (224.69 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.99 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.9930 mL	24.9650 mL	49.9301 mL	249.6505 mL
5 mM	0.9986 mL	4.9930 mL	9.9860 mL	49.9301 mL
10 mM	0.4993 mL	2.4965 mL	4.9930 mL	24.9650 mL
20 mM	0.2497 mL	1.2483 mL	2.4965 mL	12.4825 mL
50 mM	0.0999 mL	0.4993 mL	0.9986 mL	4.9930 mL
100 mM	0.0499 mL	0.2497 mL	0.4993 mL	2.4965 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

α-adrenergic receptor Tetrahydrozoline ophthalmic nasal Inhibitor inhibit conjunctival congestion Beta Receptor AdrenergicReceptor Adrenergic Receptor

Tetrahydrozoline

Tetrahydrozoline