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Methacholine Chloride

Name: Methacholine Chloride
Brand: TargetMol
SKU: T1682
Price: 166 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.74%

货号 T1682Cas号 62-51-1

别名 氯化乙酰甲胆碱, 醋甲胆碱, Mecholyl chloride, Acetyl-β-methylcholine chloride

Methacholine Chloride (Acetyl-β-methylcholine chloride) 是副交感神经系统中的毒蕈碱-3 受体激动剂。它可用于测量气道高反应性，作为评估哮喘样症状和正常静息呼气流速的诊断辅助手段。它直接作用于平滑肌上的乙酰胆碱受体，引起收缩和气道狭窄。

Methacholine Chloride

一键复制产品信息

很棒

纯度: 99.74%

货号 T1682 别名 氯化乙酰甲胆碱, 醋甲胆碱, Mecholyl chloride, Acetyl-β-methylcholine chlorideCas号 62-51-1

规格	价格	库存
10 mg	¥ 166	现货
25 mg	¥ 248	现货
50 mg	¥ 349	现货
100 mg	¥ 498	现货
500 mg	¥ 1,190	现货
1 mL x 10 mM (in DMSO)	¥ 398	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.37%

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资源下载:

COA LCMS HNMR 产品操作手册

产品介绍

Methacholine Chloride AI Summary

Methacholine Chloride exhibits a wide range of bioactivities. It acts as a potent inhibitor in various assays including those targeting Tau fibril formation, Bloom's syndrome helicase, Histone Lysine Methyltransferase G9a, delayed death of the malarial parasite, Polymerase Iota, Hepatitis C Virus, GLP-1 receptor inverse agonists, human tyrosyl-DNA phosphodiesterase 1, human Apurinic/apyrimidinic Endonuclease 1, and Ebola virus entry. Additionally, it enhances the expression of the SMN2 splice variant and inhibits Nrf2. The compound's potency ranges from nanomolar to micromolar levels, with specific IC50 and AC50 values across various bioassays. It significantly inhibits sodium fluorescein uptake in OATP1B3- and OATP1B1-transfected CHO cells at a 10 μM concentration, with inhibitions of 106.87% and 86.62%, respectively. Furthermore, Methacholine Chloride acts as an agonist at the muscarinic acetylcholine receptor in guinea pig ileum, displaying a pD2 value of 7.02, which denotes its potency in activating this receptor. However, it shows very low activity in inhibiting cell viability in Vero E6 cells infected with SARS-CoV-2, with an inhibition index of 0.009846, indicating minimal effectiveness in this context..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述

Methacholine Chloride (Acetyl-β-methylcholine chloride) is a quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma.

别名

氯化乙酰甲胆碱, 醋甲胆碱, Mecholyl chloride, Acetyl-β-methylcholine chloride

化学信息

分子量	195.69
分子式	C₈H₁₈ClNO₂
CAS No.	62-51-1
Smiles	[Cl-].CC(C[N+](C)(C)C)OC(C)=O
密度	1.1028 g/cm3 (Estimated)

储存&溶解度

存储

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (255.51 mM), Sonication is recommended.

H2O: 100 mg/mL (511.01 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (10.22 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	5.1101 mL	25.5506 mL	51.1012 mL	255.5062 mL
5 mM	1.0220 mL	5.1101 mL	10.2202 mL	51.1012 mL
10 mM	0.5110 mL	2.5551 mL	5.1101 mL	25.5506 mL
20 mM	0.2555 mL	1.2775 mL	2.5551 mL	12.7753 mL
50 mM	0.1022 mL	0.5110 mL	1.0220 mL	5.1101 mL
100 mM	0.0511 mL	0.2555 mL	0.5110 mL	2.5551 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Muscarinic acetylcholine receptor Methacholine Chloride Methacholine Mecholyl Chloride mAChR Inhibitor inhibit bronchoconstriction asthma-like airway hyperresponsiveness Acetyl-β-methylcholine Chloride Acetyl-b-methylcholine Chloride Acetyl-beta-methylcholine Chloride

Methacholine Chloride

Methacholine Chloride