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Bronopol

Name: Bronopol
Brand: TargetMol
SKU: T0880
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.85%

货号 T0880Cas号 52-51-7

别名 溴硝醇, 布波尔, BNPK, BNPD

Bronopol (BNPD) 是一种抗菌剂，对哺乳动物毒性低和对革兰氏阴性菌活性高。

Bronopol

一键复制产品信息

很棒

纯度: 99.85%

货号 T0880 别名 溴硝醇, 布波尔, BNPK, BNPDCas号 52-51-7

Bronopol (BNPD) 是一种抗菌剂，对哺乳动物毒性低和对革兰氏阴性菌活性高。

规格	价格	库存
25 g	¥ 99	现货
50 g	¥ 132	现货
1 mL x 10 mM (in DMSO)	¥ 420	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.85%

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COA LCMS HNMR 产品操作手册

产品介绍

Bronopol AI Summary

Bronopol exhibits a diverse range of bioactivities. It shows inhibitory activity against targets such as Lamin A splicing, ROR gamma transcriptional activity, Bacillus subtilis Sfp phosphopantetheinyl transferase, GCN5L2, T. brucei phosphofructokinase, Histone Lysine Methyltransferase G9a, Glutaminase (GLS), Trypanosoma brucei, and human tyrosyl-DNA phosphodiesterase 1 (TDP1). It acts as an agonist towards retinoid X receptor alpha signaling, thyroid hormone receptor beta signaling, the antioxidant response element (ARE) signaling pathway, and Nrf2-dependent transcriptional activity. Furthermore, it exhibits antagonistic activity against vitamin D receptor signaling and retinoid X receptor alpha signaling. Bronopol induces DNA re-replication in MCF 10a normal breast cells and SW480 colon adenocarcinoma cells. It also affects various cellular responses, such as Schwann cell viability, firefly luciferase enzyme activity, NPC, nuclear beta-catenin stimulation in WNT3A conditioned C2C12 cells, and VEGF-stimulated ADSC/ECFC co-culture. Significantly, it does not inhibit human BSEP, MRP2, MRP3, or MRP4, with IC50 values for these activities being greater than 133,000.0 nM. It demonstrates potent antiviral activities, notably inhibiting SARS-CoV-2-induced cytotoxicity in Caco-2 cells with an inhibition rate of -9.83% at a concentration of 10 µM after 48 hours, and inhibiting SARS-CoV-2 3CL-Pro protease with a 100.41% inhibition at 20 µM and an IC50 value of 420.0 nM. In contrast, its inhibition of the MERS 3CL protease is less significant, showing only 14.0% inhibition at 10 µM and an IC50 value greater than 10,000.0 nM. Additionally, Bronopol shows significant inhibitory activity for human HDAC6 enzyme with an inhibition rate of 135.55% using a commercial peptide substrate, and 8.53% using a custom peptide substrate. These findings suggest potential bioactivities related to HDAC6 inhibition..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Bronopol (BNPD) is an antimicrobial agent with low mammalian toxicity (at in-use levels) and high activity against bacteria, especially the troublesome Gram-negative species.
别名	溴硝醇, 布波尔, BNPK, BNPD

化学信息

分子量	199.99
分子式	C₃H₆BrNO₄
CAS No.	52-51-7
Smiles	OCC(Br)(CO)[N+]([O-])=O
密度	2.0002 g/cm3 (Estimated)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: 36 mg/mL (180.01 mM), Sonication is recommended.

DMSO: 245 mg/mL (1225.06 mM), Sonication is recommended.

Ethanol: 37 mg/mL (185.01 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (10 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

H2O/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.0003 mL	25.0013 mL	50.0025 mL	250.0125 mL
5 mM	1.0001 mL	5.0003 mL	10.0005 mL	50.0025 mL
10 mM	0.5000 mL	2.5001 mL	5.0003 mL	25.0013 mL
20 mM	0.2500 mL	1.2501 mL	2.5001 mL	12.5006 mL
50 mM	0.1000 mL	0.5000 mL	1.0001 mL	5.0003 mL
100 mM	0.0500 mL	0.2500 mL	0.5000 mL	2.5001 mL