SARS-CoV-2-IN-14

Name: SARS-CoV-2-IN-14
Brand: TargetMol
SKU: T60538
Price: 108 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.78%

货号 T60538Cas号 22203-98-1

别名 3',5-Dichlorosalicylanilide

SARS-CoV-2-IN-14 是一种有效的、可口服的 SARS-CoV-2 抑制剂（IC50 ：0.39 μM），是一种氯硝柳胺类似物。SARS-CoV-2-IN-14在人血浆和肝 S9 酶测定中比氯硝柳胺稳定性更强。SARS-CoV-2-IN-14以口服的方式给药可以提高其生物利用度和半衰期。

为众多的药物研发团队赋能，

让新药发现更简单！

SARS-CoV-2-IN-14

一键复制产品信息

很棒

纯度: 99.78%

货号 T60538 别名 3',5-DichlorosalicylanilideCas号 22203-98-1

规格	价格	库存
1 mg	¥ 108	现货
5 mg	¥ 221	现货
10 mg	¥ 359	现货
25 mg	¥ 648	现货
50 mg	¥ 978	现货
100 mg	¥ 1,450	现货
200 mg	¥ 2,150	现货
1 mL x 10 mM (in DMSO)	¥ 226	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.78%

联系我们获取更多批次信息

资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

SARS-CoV-2-IN-14 AI Summary

SARS-CoV-2-IN-14 exhibits a range of bioactivities, including significant antimycobacterial effects, antiviral properties, and inhibition of specific biochemical pathways and receptors. It shows activity against various Mycobacterium strains, such as Mycobacterium tuberculosis, Mycobacterium avium, and Mycobacterium kansasii, with MIC values ranging from 4000.0 nM to 16000.0 nM. In HEK293 cells, it inhibits the Wnt/beta-catenin pathway with an IC50 of 1650.0 nM. Moreover, it reduces the activity of Cryptosporidium hominis TS-DHFR enzyme by 54% at 500 uM. In terms of receptor antagonism, SARS-CoV-2-IN-14 inhibits ATP-induced calcium influx at the human P2X1 receptor (P2X2/P2X1 chimera) with an IC50 of 75.6 nM and 64.0% inhibition at 10 uM pre-incubation, and shows moderate inhibition at the P2X4 receptor with an IC50 of 135.0 nM. It does not significantly affect P2X2, P2X3, or P2X7 receptors, with IC50 values above 10000.0 nM. The compound demonstrates antiviral activity against SARS-CoV-2 in African Green monkey Vero cells with an IC50 of 390.0 nM and cytotoxicity in Vero E6 cells with a CC50 of 2460.0 nM, giving a selectivity ratio of 6.3. It has a permeability of 8.6 x 10^-6 cm/s, low water solubility (<1.0 ug/mL), 71.0% stability in human plasma, and 33.0% metabolic stability in human liver microsomes. Additionally, it exhibits cytotoxicity against Vero E6 cells preincubated for 2 hours, followed by SARS-CoV-2 addition, with a CC50 of 100000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	SARS-CoV-2-IN-14 is a potent and oral inhibitor of SARS-CoV-2 (IC50:0.39 μM), which is an analogue of niclosamide. SARS-CoV-2-IN-14 was more stable than niclosamide in the determination of human plasma and liver S9 enzyme. Oral administration of SARS-CoV-2-IN-14 can improve its bioavailability and half-life.
靶点活性	SARS-CoV-2:0.39 μM
别名	3',5-Dichlorosalicylanilide

化学信息

分子量	282.12
分子式	C₁₃H₉Cl₂NO₂
CAS No.	22203-98-1
Smiles	C(NC1=CC(Cl)=CC=C1)(=O)C2=C(O)C=CC(Cl)=C2

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 9 mg/mL (31.9 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5446 mL	17.7230 mL	35.4459 mL	177.2295 mL
5 mM	0.7089 mL	3.5446 mL	7.0892 mL	35.4459 mL
10 mM	0.3545 mL	1.7723 mL	3.5446 mL	17.7230 mL
20 mM	0.1772 mL	0.8861 mL	1.7723 mL	8.8615 mL