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Miconazole

Name: Miconazole
Brand: TargetMol
SKU: T0344
Price: 136 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.89%

货号 T0344Cas号 22916-47-8

别名 咪康唑, R18134

Miconazole (R18134) 是一种具有抗菌作用的咪唑类抗真菌剂。

Miconazole

一键复制产品信息

很棒

纯度: 99.89%

货号 T0344 别名 咪康唑, R18134Cas号 22916-47-8

Miconazole (R18134) 是一种具有抗菌作用的咪唑类抗真菌剂。

规格	价格	库存	数量
100 mg	¥ 136	现货
500 mg	¥ 289	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.89%

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产品介绍

Miconazole AI Summary

Miconazole exhibits potent antifungal activity against a variety of fungal pathogens, particularly against Candida species and dermatophytes. It shows high efficacy with low minimum inhibitory concentrations (MIC) ranging from 0.156 to 25.0 ug/mL, indicating strong inhibitory effects against Candida albicans, Aspergillus fumigatus, Trichophyton mentagrophytes, and others. Additionally, Miconazole demonstrates fungicidal activity with MIC values often below 0.78 ug/mL for some dermatophytes like Microsporum canis and Trichophyton asteroides. In in vivo studies, Miconazole significantly inhibits fungal infections in animal models such as guinea pigs and hamsters, reducing lesion scores and fungal culture positivity. It enhances the activity of enzymes like styrene oxide hydrolase and epoxide hydrolase, indicated by specific enhancement metrics and partition coefficients like LogP (5.84). The compound is also an effective inhibitor of Cytochrome P450 enzymes, particularly CYP51, and shows inhibitory activity against Cytochrome P450 3A4 with relevant IC50 values, contributing to its wide spectrum of bioactivity. Moreover, Miconazole exhibits inhibitory effects on other enzymes and proteins, including beta-lactamase, malate dehydrogenase, and Tdo2. The compound's bioactivity spectrum extends to showing cytotoxicity in human cell lines and specific antimicrobial activity against various bacterial strains, although it demonstrates moderate to low antibacterial efficacy. Overall, Miconazole is a promising antifungal agent with potential applications in treating diverse fungal infections..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Miconazole (R18134) is an imidazole antifungal agent that is used topically and by intravenous infusion.
别名	咪康唑, R18134

化学信息

分子量	416.13
分子式	C₁₈H₁₄Cl₄N₂O
CAS No.	22916-47-8
Smiles	C(CN1C=CN=C1)(OCC2=C(Cl)C=C(Cl)C=C2)C3=C(Cl)C=C(Cl)C=C3
密度	1.4g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 250 mg/mL (600.77 mM), Sonication is recommended.

Ethanol: 77 mg/mL (185.04 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.81 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4031 mL	12.0155 mL	24.0310 mL	120.1548 mL
5 mM	0.4806 mL	2.4031 mL	4.8062 mL	24.0310 mL
10 mM	0.2403 mL	1.2015 mL	2.4031 mL	12.0155 mL
20 mM	0.1202 mL	0.6008 mL	1.2015 mL	6.0077 mL
50 mM	0.0481 mL	0.2403 mL	0.4806 mL	2.4031 mL
100 mM	0.0240 mL	0.1202 mL	0.2403 mL	1.2015 mL