GSK4112

Name: GSK4112
Brand: TargetMol
SKU: T5045
Price: 111 CNY
Availability: InStock
Rating: 5 (10 reviews)

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产品编号 T5045Cas号 1216744-19-2

别名 SR6452, 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate

GSK4112 (SR6452) 是一种 Rev-erbα 激动剂，EC50 为 0.4 μM。它也是一种用于核血红素受体 Rev-erbα 的细胞生物学的小分子化学探针。

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纯度: 99.69%

产品编号 T5045 别名 SR6452, 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinateCas号 1216744-19-2

GSK4112 (SR6452) 是一种 Rev-erbα 激动剂，EC50 为 0.4 μM。它也是一种用于核血红素受体 Rev-erbα 的细胞生物学的小分子化学探针。

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GSK4112 相关产品

产品介绍

生物活性

产品描述	GSK4112 (SR6452) is a Rev-erbα agonist with EC50 of 0.4 μM, also is a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα.
靶点活性	Rev-Erbα:0.4 μM(EC50)
体外活性	GSK4112 profiled as a Rev-erb agonist in cells to inhibit expression of the circadian target gene bmal1. In addition, GSK4112 repressed the expression of gluconeogenic genes in liver cells and reduced glucose output in primary hepatocytes. Therefore, GSK4112 is useful as a chemical tool to probe the function of Rev-erb in transcriptional repression, regulation of circadian biology, and metabolic pathways. Additionally, GSK4112 may serve as a starting point for design of Rev-erb chemical probes with in vivo pharmacologicalm activity.
别名	SR6452, 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate

化学信息

分子量	396.89
分子式	C₁₈H₂₁ClN₂O₄S
CAS No.	1216744-19-2
Smiles	CC(C)(C)OC(=O)CN(Cc1ccc(s1)[N+]([O-])=O)Cc1ccc(Cl)cc1
密度	1.296 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 9.9 mg/mL (24.94 mM), Sonication is recommended.

溶液配制表

DMSO