GSK8573

Name: GSK8573
Brand: TargetMol
SKU: T15441
Price: 173 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.97%

货号 T15441Cas号 1693766-04-9

GSK8573 是 GSK2801 的非活性对照化合物。它与BRD9具有结合活性，Kd 值为 1.04 μM。

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GSK8573

一键复制产品信息

很棒

纯度: 99.97%

货号 T15441Cas号 1693766-04-9

GSK8573 是 GSK2801 的非活性对照化合物。它与BRD9具有结合活性，Kd 值为 1.04 μM。

规格	价格	库存
1 mg	¥ 173	现货
5 mg	¥ 330	现货
10 mg	¥ 517	现货
25 mg	¥ 973	现货
50 mg	¥ 1,530	现货
100 mg	¥ 2,170	现货
1 mL x 10 mM (in DMSO)	¥ 233	现货

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COA HNMR LCMS 产品操作手册

产品介绍

GSK8573 AI Summary

GSK8573 exhibits selective bioactivity characterized by its binding affinity with various proteins such as BRD9, SMARCA2, and SMARCA4 in human HUT78 cell extract, and with biotinylated C-terminal Avi/His-TEV-fused BRD9 expressed in Escherichia coli. Affinity levels vary with each protein, indicated by Kd values from chemoproteomic competition binding assays and isothermal titration calorimetric (ITC) analysis. Thermal Shift Assays reveal that GSK8573 can both increase and decrease melting temperatures (Delta TM) of different protein domains, indicating complex interactions with protein structures. In cellular assays, GSK8573 impacts cell viability variably across different cell lines. It shows no significant growth effect in HEK293T and most U2OS cell assays, along with human fibroblasts, but some U2OS and fibroblast assays report a growth rate increase. The compound also demonstrates low bioactivity regarding BAZ2A and BAZ2B targets, with IC50 values over 100,000 nM and Kd values exceeding 10,000 nM, indicating weak or negligible interaction. Additionally, in Bromodomain panel assays, GSK8573 shows a relative signal of 0.04 with BRD9 and less than -0.05 with BAZ2A. ITC assays report a Kd value of 1040.0 nM with BRD9, suggesting a moderately higher affinity with this target. Overall, GSK8573's bioactivity varies substantially with different proteins and cell types, showing specificity and differential binding affinities..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	GSK8573 is an inactive control compound for GSK2801. GSK8573 has binding activity to BRD9 (Kd of 1.04 μM).
靶点活性	BRD9:1.04 μM (Kd)

化学信息

分子量	323.39
分子式	C₂₀H₂₁NO₃
CAS No.	1693766-04-9
Smiles	CCCOc1ccn2c(cc(-c3cccc(OC)c3)c2c1)C(C)=O
密度	1.12 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 22 mg/mL (68.03 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.18 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0922 mL	15.4612 mL	30.9224 mL	154.6121 mL
5 mM	0.6184 mL	3.0922 mL	6.1845 mL	30.9224 mL
10 mM	0.3092 mL	1.5461 mL	3.0922 mL	15.4612 mL
20 mM	0.1546 mL	0.7731 mL	1.5461 mL	7.7306 mL
50 mM	0.0618 mL	0.3092 mL	0.6184 mL	3.0922 mL