(Z)-Capsaicin

Name: (Z)-Capsaicin
Brand: TargetMol
SKU: T1109
Price: 494 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 98.91%

货号 T1109Cas号 25775-90-0

别名 珠卡赛辛, Zucapsaicin, Civamide, cis-Capsaicin, (Z)-辣椒素

(Z)-Capsaicin (Zucapsaicin) 是天然辣椒素的合成顺式异构体，用于治疗膝骨关节炎。它是一种可口服的 TRPV1激动剂，可研究神经性疼痛。

(Z)-Capsaicin

一键复制产品信息

很棒

纯度: 98.91%

货号 T1109 别名 珠卡赛辛, Zucapsaicin, Civamide, cis-Capsaicin, (Z)-辣椒素Cas号 25775-90-0

(Z)-Capsaicin (Zucapsaicin) 是天然辣椒素的合成顺式异构体，用于治疗膝骨关节炎。它是一种可口服的 TRPV1激动剂，可研究神经性疼痛。

规格	价格	库存
10 mg	¥ 494	现货
50 mg	¥ 1,591	现货
100 mg	¥ 2,281	现货
200 mg	¥ 3,194	现货

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COA HNMR LCMS 产品操作手册

产品介绍

(Z)-Capsaicin AI Summary

(Z)-Capsaicin demonstrates significant bioactivity across various assays and targets. In vivo, subcutaneous administration at 40 mg/kg in a mouse hot plate test resulted in a latency time greater than 39.9, with 6 out of 7 animals responding. However, it showed 0.0% analgesia in a rat hot plate test after oral administration at 300 mg/kg. Topically, it inhibited Croton oil-induced inflammation in a mouse ear test by 79.5%. The compound also exhibited acute toxicity with a 50% lethality rate at 50 mg/kg intraperitoneally in mice. In vitro, (Z)-Capsaicin exhibits broad-spectrum inhibitory activities, including against human Jumonji Domain Containing 2E (JMJD2E), Cruzain, Cytochrome P450 enzymes (2C19, 2D6, 2C9, 3A4), and Aldehyde Dehydrogenase 1 (ALDH1A1). It also inhibits Anthrax Lethal Toxin Internalization and Caspase-1. Additionally, it acts as an activator of Cytochrome P450 3A4 and exhibits modulation of TRPV1 receptors with a Ki value of 1080 nM and agonist activity with an EC50 value of 28.2 nM, increasing 45Ca2+ uptake. (Z)-Capsaicin shows inhibitory activity against the SARS-CoV-2 3CL-Pro protease, with 12.44% inhibition at 20 μM detected via FRET assay. In cellular assays, it demonstrated minimal antiviral activity against SARS-CoV-2-induced cytotoxicity in VERO-6 cells at 10 μM concentration. The compound also displays antifungal effects against Candida albicans and antibacterial activity against multiple bacterial strains, including Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, and Staphylococcus aureus MRSA, suggesting potential as a broad-spectrum antimicrobial agent..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	(Z)-Capsaicin (Zucapsaicin) is a medication used to treat osteoarthritis of the knee and Others neuropathic pain.(Z)-Capsaicin is a synthetic cis isomer of natural capsaicin that has shown therapeutic efficacy in pain accompanying osteoarthritis of the knee.
别名	珠卡赛辛, Zucapsaicin, Civamide, cis-Capsaicin, (Z)-辣椒素

化学信息

分子量	305.41
分子式	C₁₈H₂₇NO₃
CAS No.	25775-90-0
Smiles	COC1=C(O)C=CC(CNC(=O)CCCC\C=C/C(C)C)=C1
密度	1.041g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 60 mg/mL (196.46 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.55 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2743 mL	16.3714 mL	32.7429 mL	163.7144 mL
5 mM	0.6549 mL	3.2743 mL	6.5486 mL	32.7429 mL
10 mM	0.3274 mL	1.6371 mL	3.2743 mL	16.3714 mL
20 mM	0.1637 mL	0.8186 mL	1.6371 mL	8.1857 mL
50 mM	0.0655 mL	0.3274 mL	0.6549 mL	3.2743 mL
100 mM	0.0327 mL	0.1637 mL	0.3274 mL	1.6371 mL