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顶部相关产品产品介绍化学信息储存和溶解信息计算器

6α-Methylprednisolone 21-hemisuccinate sodium salt

Synonyms: 甲强龙琥珀酸钠, Metypresol, Methylprodnisolone Sodium Succinate, Methylprednisolone sodium succinate, Corticel, Asmacortone, 6-Methylprednisolone succinate sodium
货号 T0294Cas号 2375-03-3 一键复制产品信息纯度: 99.65%
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6α-Methylprednisolone 21-hemisuccinate sodium salt (Asmacortone) 是一种糖皮质激素，是一种有效的抗炎剂，半衰期比 Prednisolone 长。

6α-Methylprednisolone 21-hemisuccinate sodium salt

一键复制产品信息
Rating icon 很棒

纯度: 99.65%

货号 T0294Cas号 2375-03-3

别名 甲强龙琥珀酸钠, Metypresol, Methylprodnisolone Sodium Succinate, Methylprednisolone sodium succinate, Corticel, Asmacortone, 6-Methylprednisolone succinate sodium

6α-Methylprednisolone 21-hemisuccinate sodium salt (Asmacortone) 是一种糖皮质激素，是一种有效的抗炎剂，半衰期比 Prednisolone 长。

6α-Methylprednisolone 21-hemisuccinate sodium salt
其他形式的 “6α-Methylprednisolone 21-hemisuccinate sodium salt”:
Methylprednisolone succinate (Standard)
Methylprednisolone succinate
规格价格库存数量
5 mg
¥ 283
现货
10 mg
¥ 452
现货
25 mg
¥ 817
现货
50 mg
¥ 1,370
现货
100 mg
¥ 1,980
现货
200 mg
¥ 2,930
现货
500 mg
¥ 4,860
现货
1 mL x 10 mM (in DMSO)
¥ 297
现货
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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂
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纯度: 99.65%
性状: solid
资源下载: COA LCMS HNMR产品操作手册

产品介绍

6α-Methylprednisolone 21-hemisuccinate sodium salt AI Summary
6α-Methylprednisolone 21-hemisuccinate sodium salt exhibits multiple pharmacological activities, including neuroprotective, cytoprotective, and antiviral properties. It inhibits iron-dependent lipid peroxidation in rat brain homogenates with an IC50 reported as 0.0 nM, and demonstrates neuroprotective efficacy in a mouse head injury model, with a noted dose of 13.5 mg/kg improving grip scores post-injury; the lowest effective dose in this model is 15.0 mg/kg. Moreover, at a chemical dosage of 100 mg/kg, 6α-Methylprednisolone 21-hemisuccinate sodium salt increases the LD50 by 20.0% in a cytotoxic hypoxia model involving male CF-1 mice. Additionally, it exhibits inhibitory activity against the SARS-CoV-2 3CL-Pro protease with an inhibition percentage of 0.6895% at 20 µM, indicating potential antiviral activity. The compound also shows some antiviral activity against SARS-CoV-2-induced cytotoxicity in different cell types, including Caco-2 and VERO-6 cells, although the inhibition rates vary, with notable activity at concentrations of 10 µM after 48 hours. Lastly, in a PubChem BioAssay, 6α-Methylprednisolone 21-hemisuccinate sodium salt demonstrated a potency of 3758.6 nM as an inhibitor of human tyrosyl-DNA phosphodiesterase 1 (TDP1) in the presence of camptothecin (CPT)..
Note: Summary generated by AI. Data source: ChEMBL
生物活性
产品描述
6α-Methylprednisolone 21-hemisuccinate sodium salt (Asmacortone), a water-soluble ester, is used for allergic, cardiac, and hypoxic emergencies.
别名
甲强龙琥珀酸钠, Metypresol, Methylprodnisolone Sodium Succinate, Methylprednisolone sodium succinate, Corticel, Asmacortone, 6-Methylprednisolone succinate sodium
化学信息
分子量496.53
分子式C26H33NaO8
CAS No.2375-03-3
Smiles[Na+].C[C@H]1C[C@H]2[C@@H]3CC[C@](O)(C(=O)COC(=O)CCC([O-])=O)[C@@]3(C)C[C@H](O)[C@@H]2[C@@]2(C)C=CC(=O)C=C12
密度no data available
储存&溶解度
存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息
DMSO: 237.5 mg/mL (478.32 mM), Sonication is recommended.
体内实验配方
10% DMSO+90% Saline: 10 mg/mL (20.14 mM), Solution.
10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1.5 mg/mL (3.02 mM), Sonication is recommended.
请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。
溶液配制表
DMSO
1mg5mg10mg50mg
1 mM2.0140 mL10.0699 mL20.1398 mL100.6989 mL
5 mM0.4028 mL2.0140 mL4.0280 mL20.1398 mL
10 mM0.2014 mL1.0070 mL2.0140 mL10.0699 mL
20 mM0.1007 mL0.5035 mL1.0070 mL5.0349 mL
50 mM0.0403 mL0.2014 mL0.4028 mL2.0140 mL
100 mM0.0201 mL0.1007 mL0.2014 mL1.0070 mL
该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD， 玉米油等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

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