store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PHGDH-IN-3 是一种具有口服活性的磷酸甘油酸脱氢酶 (PHGDH) 抑制剂, 对 PHGDH 具有抑制作用,IC50 值为 2.8 μM。PHGDH-IN-3 可用于研究癌症。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 993 | 现货 | ||
2 mg | ¥ 1,450 | 现货 | ||
5 mg | ¥ 2,380 | 现货 | ||
10 mg | ¥ 3,560 | 现货 | ||
25 mg | ¥ 5,720 | 现货 | ||
50 mg | ¥ 7,630 | 现货 | ||
100 mg | ¥ 9,870 | 现货 | ||
500 mg | ¥ 19,800 | 现货 |
产品描述 | PHGDH-IN-3 is an orally active phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 2.8 μM against PHGDH. PHGDH-IN-3 can be used in studies about cancer. |
靶点活性 | PHGDH:2.8 μM, PHGDH:2.33 μM |
体外活性 |
PHGDH-IN-3 (compound D8) has good enzymatic inhibitory activity with an IC50 value of 2.8 μM.[1] PHGDH-IN-3 has a high binding affinity for PHGDH protein with a Kd value of 2.33 μM.[1] PHGDH-IN-3 is sensitive to cell lines with amplified or overexpressed PHGDH genes.[1] PHGDH-IN-3 restricts the de novo synthesis of serine from glucose in MDA-MB-468 cells.[1] |
体内活性 |
PHGDH-IN-3 (compound D8) (1, 3 mg/kg; p.o., i.v.; ) exhibits excellent in vivo pharmacokinetic properties.[1] PHGDH-IN-3 (12.5, 25, 50 mg/kg; i.p.; once daily for 31 days) exerted significant antitumor effects in a PC9 xenograft mouse model.[1] |
分子量 | 495.55 |
分子式 | C24H18FN3O4S2 |
CAS No. | 2893778-31-7 |
store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90.0 mg/mL (181.6 mM), Sonication and heating to 70℃ are recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.018 mL | 10.0898 mL | 20.1796 mL | 50.449 mL |
5 mM | 0.4036 mL | 2.018 mL | 4.0359 mL | 10.0898 mL | |
10 mM | 0.2018 mL | 1.009 mL | 2.018 mL | 5.0449 mL | |
20 mM | 0.1009 mL | 0.5045 mL | 1.009 mL | 2.5224 mL | |
50 mM | 0.0404 mL | 0.2018 mL | 0.4036 mL | 1.009 mL | |
100 mM | 0.0202 mL | 0.1009 mL | 0.2018 mL | 0.5045 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
PHGDH-IN-3 2893778-31-7 Metabolism Dehydrogenase Inhibitor inhibitor inhibit