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- 210种泛素化相关的小分子，用于高通量和高内涵筛选；
- 作用靶点包括proteasome, E1/E2/E3 Enzyme, DUB, p97等；
- 详细的说明书，化合物结构、靶点信息、活性描述等；
- NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。
泛素化化合物库
Ubiquitination Compound Library
很棒泛素化是泛素在一系列特殊的酶催化下对靶蛋白进行特异性修饰的过程，这些特殊的酶包括泛素激活酶、结合酶、连结酶和降解酶等。泛素化被认为是蛋白质翻译后修饰的一个重要途径，在细胞凋亡、细胞周期调控、DNA 损伤修复及膜转运等细胞过程中起重要作用，与肿瘤、心血管等疾病的发病密切相关。作为近年来生物化学研究的一个重大成果，泛素化已然成为研究、开发新药物的新靶点。 TargetMol 泛素化化合物库收集了210 种泛素化相关的小分子，作用靶点包括proteasome, E1/E2/E3 Enzyme, DUB, p97等，满足泛素化相关研究的客户需求。
TargetMol 的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。
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化合物库相关信息
Excel
SDF
联系我们获取更多批次信息产品编号 L8600
泛素化化合物库规格
- 1 mg
- 30 μL x 10 mM (in DMSO)
- 50 μL x 10 mM (in DMSO)
- 100 μL x 10 mM (in DMSO)
- 250 μL x 10 mM (in DMSO)
询价 & 定制
产品描述
包装和储存
- 可选用DMSO耐受的96/384孔板或2D 条形码编码管；
- 干粉蓝冰运输，DMSO溶液干冰运输；
- 排布：96孔板：1st & 12th 空白对照，384孔板：1st & 2nd & 23th & 24th空白对照。
SCI 文献
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文献引用
1.Kim Y H, Jo D S, Park N Y, et al. Inhibition of BRD4 Promotes Pexophagy by Increasing ROS and ATM Activation. Cells. 2022, 11(18): 2839.2.Kim Y H, Park N Y, Jo D S, et al.Inhibition of VHL by VH298 Accelerates Pexophagy by Activation of HIF-1α in HeLa Cells.Molecules.2024, 29(2): 482.3.Kim S H, Bae J E, Park N Y, et al.Evaluation of Teneligliptin and Retagliptin on the Clearance of Melanosome by Melanophagy in B16F1 Cells.Cosmetics.2024, 11(2): 35.4.Kim J B, Bae J E, Park N Y, et al.Inhibition of ubiquitin specific peptidase 14 (USP14) promotes ER-phagy by inducing ER stress in human hepatoma HepG2 cells.Animal Cells and Systems.2023, 27(1): 394-402.5.Park N Y, Jo D S, Yang J Y, et al.Activation of lysophagy by a TBK1-SCFFBXO3-TMEM192-TAX1BP1 axis in response to lysosomal damage.Nature Communications.2025, 16(1): 1109.
化合物库组成
Proteasome
E1/E2/E3 Enzyme
DUB
Apoptosis
Autophagy
p53
DPP-4
Mdm2
Ferroptosis
NF-κB
p97
Cysteine Protease
Sirtuin
PROTACs
HIV Protease
NEDD8
Dehydrogenase
Epigenetic Reader Domain
Antibacterial
IκB/IKK
DNA Alkylator/Crosslinker
Caspase
IAP
Bcr-Abl
SARS-CoV
Ligand for E3 Ligase
Antibiotic
Src
Amino Acids and Derivatives
Antifungal
Mitophagy
Factor Xa
PPAR
PARP
Serine Protease
Aryl Hydrocarbon Receptor
RIP kinase
PDE
Molecular Glues
BCL
Reactive Oxygen Species
JAK
IGF-1R
COX
HSP
Aminopeptidase
Neprilysin
Endogenous Metabolite
HDAC
AMPK
TNF
Potassium Channel
Syk
BMI-1
DNA Methyltransferase
TAM Receptor
Protease-activated Receptor
HIF/HIF Prolyl-Hydroxylase
化合物库信息
| Empty | 960374-59-8 | 945667-22-1 | 939981-39-2 | 935888-69-0 | 924296-39-9 | 924296-19-5 | 924296-18-4 | 924296-17-3 | 919091-63-7 | 916232-21-8 | Empty |
| ONX-0914 | Saxagliptin hydrate | RG7112 | Oprozomib | HBX 41108 | DUB-IN-2 | DUB-IN-1 | DUB-IN-3 | RA-9 | GS143 | ||
| Empty | 916170-19-9 | 911637-19-9 | 906093-29-6 | 905579-51-3 | 890605-54-6 | 882257-11-6 | 88191-84-8 | 881202-45-5 | 880813-36-5 | 874146-69-7 | Empty |
| AC-55541 | Gemigliptin | Teneligliptin hydrobromide | Pevonedistat | Heclin | P005091 | MDL-28170 | Serdemetan | PhiKan 083 | PK11007 | ||
| Empty | 865759-25-7 | 864420-54-2 | 862974-25-2 | 858557-69-4 | 858134-23-3 | 856849-35-9 | 856243-80-6 | 850649-62-6 | 850649-61-5 | 847499-27-8 | Empty |
| Trelagliptin | NAE-IN-M22 | N106 | MUN57694 | Vialinin A | Proteasome inhibitor IX | Degrasyn | Alogliptin Benzoate | Alogliptin | Delanzomib | ||
| Empty | 83-79-4 | 82009-34-5 | 81840-15-5 | 81624-55-7 | 81110-73-8 | 803647-40-7 | 739366-20-2 | 71555-25-4 | 700-06-1 | 697797-51-6 | Empty |
| Rotenone | Cilastatin | Vesnarinone | NSC348884 | Racecadotril | NSC59984 | Anagliptin | ZMC1 | Indole-3-carbinol | UAMC00039 dihydrochloride | ||
| Empty | 6964-62-1 | 675576-98-4 | 675576-97-3 | 670270-31-2 | 668467-91-2 | 668270-12-0 | 66592-89-0 | 65836-72-8 | 654671-78-0 | 64984-31-2 | Empty |
| NSC 66811 | Nutlin-3a | Nutlin-3b | IU1-47 | LDN-57444 | Linagliptin | Kevetrin hydrochloride | DKM 2-93 | Sitagliptin phosphate | Pifithrin-μ | ||
| Empty | 63476-70-0 | 63388-44-3 | 63208-82-2 | 61276-17-3 | 60477-38-5 | 58-60-6 | 58131-57-0 | 569-83-5 | 56974-61-9 | 5608-24-2 | Empty |
| Benzonitrile, 3,3'-[(2-oxo-1,3-cyclohexanediylidene)dimethylidyne]bis- | SJB2-043 | Pifithrin-α hydrobromide | Verbascoside | Pifithrin-α, p-Nitro, Cyclic | Puromycin aminonucleoside | XI-006 | 1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one | Gabexate mesylate | PRIMA-1 | ||
| Empty | 548472-68-0 | 5291-32-7 | 528-43-8 | 511296-88-1 | 5092-09-1 | 5041-81-6 | 487-36-5 | 486460-32-6 | 486-21-5 | 439946-22-2 | Empty |
| Nutlin-3 | Eprenetapopt | Magnolol | Pifithrin-β hydrobromide | Saikogenin A | Isoliquiritin | Pinoresinol | Sitagliptin | Isofraxidin | LDN-91946 | ||
| Empty | 432001-69-9 | 431979-47-4 | 4272-74-6 | 423148-78-1 | 418805-02-4 | 402-71-1 | 38275-34-2 | 380315-80-0 | 361442-04-8 | 35286-58-9 | Empty |
| Skp2 Inhibitor C1 | SJ-172550 | N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride | PYZD-4409 | PYR-41 | TPCK | PK11000 | Tenovin-1 | Saxagliptin | Ziyuglycoside I |
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