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顶部产品介绍偶联与修饰抗原信息储存和溶解信息计算器

Anti-Cortisol Binding Globulin Antibody (6B117)

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货号 TMAY-01439

别名 SerpinA6, serpin peptidase inhibitor, clade A (α-1 antiproteinase, antitrypsin), member 6, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6, Cbg, AV104445, AI265318

Anti-Cortisol Binding Globulin Antibody (6B117) 是一种 Mouse 抗体，靶向 Cortisol Binding Globulin。Anti-Cortisol Binding Globulin Antibody (6B117) 可用于 ELISA。

Anti-Cortisol Binding Globulin Antibody (6B117)

Anti-Cortisol Binding Globulin Antibody (6B117)

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货号 TMAY-01439 别名 SerpinA6, serpin peptidase inhibitor, clade A (α-1 antiproteinase, antitrypsin), member 6, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6, Cbg, AV104445, AI265318

Anti-Cortisol Binding Globulin Antibody (6B117) 是一种 Mouse 抗体，靶向 Cortisol Binding Globulin。Anti-Cortisol Binding Globulin Antibody (6B117) 可用于 ELISA。

规格价格库存数量
100 μL
¥ 1,684
5日内发货
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产品介绍

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产品描述
Anti-Cortisol Binding Globulin Antibody (6B117) is a Mouse antibody targeting Cortisol Binding Globulin. Anti-Cortisol Binding Globulin Antibody (6B117) can be used in ELISA.
别名SerpinA6, serpin peptidase inhibitor, clade A (α-1 antiproteinase, antitrypsin), member 6, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6, Cbg, AV104445, AI265318
Ig Type
Mouse IgG1
克隆号
6B117
反应种属
Human
特异性
Human Cortisol Binding Globulin/CBG
应用ELISA
推荐剂量
ELISA: 1:1000-1:2000
抗体种类
Monoclonal
宿主来源Mouse
构建方式This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human SerpinA6 (rh SerpinA6; TMPY-02041; NP_001747.2; Met1-Val405). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景Corticosteroid-binding globulin (CBG), also known as SerpinA6, is a non-inhibitory member of the serine proteinase inhibitor (serpin) superfamily. It is the high-affinity transport protein for glucocorticoids in vertebrate blood. CBG is specifically cleaved by this protease at a precise site close to its carboxy-terminus. This induces a conformation change and disrupts the binding between glucocorticoids and CBG, and promotes a significant and local release of glucocorticoids (over 90% of them are bound to CBG in human plasma). In this context, CBG directs glucocorticoids to sites of inflammation, and plays in consequence a crucial role in efficient glucocorticoid action in physiology. The SerpinA6 protein is mainly secreted by the liver. This negative acute phase protein regulates free cortisol levels in the blood and distributes cortisol to its target tissues. SerpinA6 deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo-/hypertension and muscle fatigue. There are three heritable, human CBG gene mutations that can reduce CBG-cortisol binding affinity and/or reduce circulating CBG levels.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: Human SerpinA6 Protein (TMPY-02041)
抗原种属
Human
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.
存储-20°C for 1 year

计算器

  • 稀释 计算器

关键词

AV-104445AV 104445AI-265318AI 265318
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