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Anti-Cortisol Binding Globulin Antibody (6B117)
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产品编号 TMAY-01439
别名 SerpinA6, serpin peptidase inhibitor, clade A (α-1 antiproteinase, antitrypsin), member 6, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6, Cbg, AV104445, AI265318
Anti-Cortisol Binding Globulin Antibody (6B117) 是一种 Mouse 抗体，靶向 Cortisol Binding Globulin。Anti-Cortisol Binding Globulin Antibody (6B117) 可用于 ELISA。
Anti-Cortisol Binding Globulin Antibody (6B117)
331 Anti-Cortisol Binding Globulin Antibody (6B117)
还可以产品编号 TMAY-01439 别名 SerpinA6, serpin peptidase inhibitor, clade A (α-1 antiproteinase, antitrypsin), member 6, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6, Cbg, AV104445, AI265318
Anti-Cortisol Binding Globulin Antibody (6B117) 是一种 Mouse 抗体，靶向 Cortisol Binding Globulin。Anti-Cortisol Binding Globulin Antibody (6B117) 可用于 ELISA。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μL | ¥ 1,684 | 5日内发货 |
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抗原信息
| 产品描述 | Anti-Cortisol Binding Globulin Antibody (6B117) is a Mouse antibody targeting Cortisol Binding Globulin. Anti-Cortisol Binding Globulin Antibody (6B117) can be used in ELISA. |
| 别名 | SerpinA6, serpin peptidase inhibitor, clade A (α-1 antiproteinase, antitrypsin), member 6, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6, Cbg, AV104445, AI265318 |
| Ig Type | Mouse IgG1 |
| 克隆号 | 6B117 |
| 交叉反应 | Human |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 1:1000-1:2000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human SerpinA6 (rh SerpinA6; TMPY-02041; NP_001747.2; Met1-Val405). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Corticosteroid-binding globulin (CBG), also known as SerpinA6, is a non-inhibitory member of the serine proteinase inhibitor (serpin) superfamily. It is the high-affinity transport protein for glucocorticoids in vertebrate blood. CBG is specifically cleaved by this protease at a precise site close to its carboxy-terminus. This induces a conformation change and disrupts the binding between glucocorticoids and CBG, and promotes a significant and local release of glucocorticoids (over 90% of them are bound to CBG in human plasma). In this context, CBG directs glucocorticoids to sites of inflammation, and plays in consequence a crucial role in efficient glucocorticoid action in physiology. The SerpinA6 protein is mainly secreted by the liver. This negative acute phase protein regulates free cortisol levels in the blood and distributes cortisol to its target tissues. SerpinA6 deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo-/hypertension and muscle fatigue. There are three heritable, human CBG gene mutations that can reduce CBG-cortisol binding affinity and/or reduce circulating CBG levels. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Human SerpinA6 Protein (TMPY-02041) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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