N,N'-Dicyclohexylurea

Name: N,N'-Dicyclohexylurea
Brand: TargetMol
SKU: T23044
Price: 108 CNY
Availability: InStock
Rating: 5 (10 reviews)

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货号 T23044Cas号 2387-23-7

别名 NSC 17013, N,N-二环己脲, Dicyclohexylurea, Dicyclohexylcarbodiamide, DCU, 1,3-Dicyclohexylurea

N,N'-Dicyclohexylurea (AURORA KA-3582) 是一种可溶性环氧化物水解酶 (sEH) 抑制剂。

N,N'-Dicyclohexylurea

一键复制产品信息

很棒

货号 T23044 别名 NSC 17013, N,N-二环己脲, Dicyclohexylurea, Dicyclohexylcarbodiamide, DCU, 1,3-DicyclohexylureaCas号 2387-23-7

N,N'-Dicyclohexylurea (AURORA KA-3582) 是一种可溶性环氧化物水解酶 (sEH) 抑制剂。

规格	价格	库存
10 mg	¥ 108	现货
25 mg	¥ 163	现货
50 mg	¥ 228	现货
100 mg	¥ 326	现货
500 mg	¥ 587	现货
1 g	¥ 828	现货

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产品介绍

N,N'-Dicyclohexylurea AI Summary

N,N'-Dicyclohexylurea exhibits a diverse range of bioactivities. It is a potent inhibitor of human recombinant soluble epoxide hydrolase (sEH) with IC50 values ranging from 25.3 nM to 52.0 nM, depending on the assay conditions. Additionally, it inhibits microsomal epoxide hydrolase activity with an IC50 of 160.0 nM. The compound also demonstrates bioactivity as an inhibitor of human Jumonji Domain Containing 2E (JMJD2E) with an IC50 of 35481.3 nM, and as a potential inhibitor of ROR gamma transcriptional activity with an IC50 of 631.0 nM. Furthermore, N,N'-Dicyclohexylurea acts as an activator of Cytochrome P450 3A4 with an IC50 of 3162.3 nM and blocks the interaction between CBF-beta and RUNX1 for potential treatment of Acute Myeloid Leukemia with an IC50 of 50118.7 nM. It also shows promise as an antiviral agent against Foot and Mouth Disease Virus with an IC50 of 1584.9 nM and exhibits some inhibition against SARS-CoV-2 3CL-Pro protease and SARS-CoV-2 induced cytotoxicity. Lastly, it has shown a 28.0% inhibition on the PTPC bioactivity in human AC16 cells at 1 uM. N,N'-Dicyclohexylurea has high solubility in sodium phosphate buffer and good metabolic stability in human liver microsomes, maintaining 100% stability without NADPH..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	N,N'-Dicyclohexylurea (AURORA KA-3582) is a soluble epoxide hydrolase (sEH) inhibitor.
别名	NSC 17013, N,N-二环己脲, Dicyclohexylurea, Dicyclohexylcarbodiamide, DCU, 1,3-Dicyclohexylurea

化学信息

分子量	224.34
分子式	C₁₃H₂₄N₂O
CAS No.	2387-23-7
Smiles	O=C(NC1CCCCC1)NC1CCCCC1
密度	1.02g/cm3

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
溶解度信息	DMSO: < 1 mg/mL (insoluble or slightly soluble), Heating is recommended.