MARK4 inhibitor 1

Name: MARK4 inhibitor 1
Brand: TargetMol
SKU: T11947
Price: 948 CNY
Availability: InStock
Rating: 5 (10 reviews)

货号 T11947Cas号 2271081-58-2 一键复制产品信息纯度: 97.7%

很棒

MARK4 inhibitor 1 是一种MARK4的抑制剂，IC50值为1.54 μM。它抑制癌细胞增殖、转移，诱导凋亡。

MARK4 inhibitor 1

一键复制产品信息

很棒

纯度: 97.7%

货号 T11947Cas号 2271081-58-2

MARK4 inhibitor 1 是一种MARK4的抑制剂，IC50值为1.54 μM。它抑制癌细胞增殖、转移，诱导凋亡。

规格	价格	库存
1 mg	¥ 948	现货
5 mg	¥ 1,830	现货
10 mg	¥ 3,390	现货
25 mg	¥ 5,520	现货
50 mg	¥ 7,730	现货
100 mg	¥ 9,870	现货

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纯度: 97.7%

颜色: 黄色

性状: Solid

资源下载: COA LCMS HNMR产品操作手册

产品介绍

MARK4 inhibitor 1 AI Summary

MARK4 inhibitor 1 exhibits a range of bioactivities that highlight its potential as an anticancer agent. It demonstrates inhibition of human recombinant MARK4 activity with an IC50 value of 1540 nM and shows a strong binding affinity to human recombinant MARK4 with a Ka value of 6.0 x 10^7/M. Additionally, it binds to human serum albumin (HSA) with a Ka value of 1.27 x 10^4/M. The compound has notable antiproliferative effects against various cancer cell lines including MCF7, MDA-MB-435S, HepG2, and HEK293, with IC50 values ranging from 6220 nM to 200000 nM. It induces apoptosis in these cell lines, as evidenced by flow cytometric analysis using Annexin V-FITC/propidium iodide staining. MARK4 inhibitor 1 also inhibits the growth of several cancer cell lines at a concentration of 10 µM after 48 hours, showing variable inhibition percentages relative to control cells. Overall, MARK4 inhibitor 1 displays promising bioactivities by inhibiting cell growth, inducing apoptosis, and interacting with key molecular targets..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	MARK4 inhibitor 1 inhibits cancer cell proliferation, metastasis and induces apoptosis. MARK4 inhibitor 1 is a potent microtubule affinity-regulating kinase 4 (MARK4) inhibitor, with an IC50 of 1.54 μM.
靶点活性	MARK4:1.54 μM

化学信息

分子量	390.4
分子式	C₂₀H₁₈N₆O₃
CAS No.	2271081-58-2
Smiles	COc1ccc(Cn2cc(nn2)C(=O)N\N=C2\C(=O)Nc3c2cccc3C)cc1
密度	1.42 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: Slightly soluble

计算器

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体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。