OUL35

Name: OUL35
Brand: TargetMol
SKU: T9024
Price: 117 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.2%

货号 T9024Cas号 6336-34-1

别名 NSC39047

OUL35 (NSC-39047) 是一种选择性 PARP-10 抑制剂和小分子 ARTD10 抑制剂，其 IC50值为 329 nM。

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OUL35

一键复制产品信息

很棒

纯度: 99.2%

货号 T9024 别名 NSC39047Cas号 6336-34-1

OUL35 (NSC-39047) 是一种选择性 PARP-10 抑制剂和小分子 ARTD10 抑制剂，其 IC50值为 329 nM。

规格	价格	库存
1 mg	¥ 117	现货
5 mg	¥ 298	现货
10 mg	¥ 497	现货
25 mg	¥ 996	现货
50 mg	¥ 1,590	现货
100 mg	¥ 2,350	现货
200 mg	¥ 3,380	现货
1 mL x 10 mM (in DMSO)	¥ 296	现货

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产品介绍

OUL35 AI Summary

OUL35 demonstrates multifaceted bioactivity as an inhibitor across various biochemical assays. It shows notable potency in inhibiting the MLL CXXC domain-DNA interaction, Aldehyde Dehydrogenase 1 (ALDH1A1), and the EPAC1 receptor. Additionally, it functions as a delayed death inhibitor of the malarial parasite plastid and impedes Lassa Virus binding or entry into cells. Significantly, it exhibits inhibitory effects on several PARP enzymes, particularly PARP10, with an IC50 of 645.65 nM, although it has lower potency and poor selectivity against other PARPs like PARP14 and PARP15. The compound effectively inhibits ARTD10 and its R931A mutant with IC50 values of 330.0 nM and 600.0 nM, respectively, while also showing stabilizing effects on the melting temperatures of ARTD family proteins. It also acts as a broad-spectrum antibacterial agent against multiple bacterial strains, although it lacks significant antifungal activity. Furthermore, OUL35 inhibits MARylation of the SRPK2 substrate for PARP10 and PARP11, with IC50 values around 1300 nM. In cellular assays, it exhibits cytoprotective activity by rescuing PARP10-induced cell death in HeLa cells with an IC50 of 1350.0 nM, while also displaying varying inhibitory potencies across different PARPs such as PARP14 and PARP15..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	OUL35 (NSC-39047) is a selective PARP-10 inhibitor, and small-molecule ARTD10 inhibitor. OUL35 has been shown to rescue cells from ARTD10-induced cell death.
靶点活性	ARTD10/PARP10:329 nM (IC50)
别名	NSC39047

化学信息

分子量	256.26
分子式	C₁₄H₁₂N₂O₃
CAS No.	6336-34-1
Smiles	NC(=O)c1ccc(Oc2ccc(cc2)C(N)=O)cc1
密度	1.298 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (214.63 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9023 mL	19.5114 mL	39.0229 mL	195.1143 mL
5 mM	0.7805 mL	3.9023 mL	7.8046 mL	39.0229 mL
10 mM	0.3902 mL	1.9511 mL	3.9023 mL	19.5114 mL
20 mM	0.1951 mL	0.9756 mL	1.9511 mL	9.7557 mL
50 mM	0.0780 mL	0.3902 mL	0.7805 mL	3.9023 mL
100 mM	0.0390 mL	0.1951 mL	0.3902 mL	1.9511 mL