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Danthron
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很棒纯度: 99.97%
货号 T0800Cas号 117-10-2
别名 丹蒽醌, Dantron, Chrysazin, Antrapurol, 1,8-二羟基蒽醌, 1,8-Dihydroxyanthraquinone
Danthron (Antrapurol) 是一种从中药 rhubarb 中提取的天然产物，可通过激活 AMPK 来调节葡萄糖和脂质代谢。
其他形式的 “Danthron”:
Danthron
一键复制产品信息 很棒纯度: 99.97%
货号 T0800 别名 丹蒽醌, Dantron, Chrysazin, Antrapurol, 1,8-二羟基蒽醌, 1,8-DihydroxyanthraquinoneCas号 117-10-2
Danthron (Antrapurol) 是一种从中药 rhubarb 中提取的天然产物，可通过激活 AMPK 来调节葡萄糖和脂质代谢。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 mg | ¥ 193 | 现货 | |
| 100 mg | ¥ 273 | 现货 | |
| 500 mg | ¥ 411 | 现货 | |
| 1 g | ¥ 619 | 现货 | |
| 5 g | ¥ 1,430 | 现货 | |
| 1 mL x 10 mM (in DMSO) | ¥ 117 | 现货 |
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产品介绍
Danthron AI Summary
Danthron demonstrates a wide range of bioactivities with notable characteristics in various assays and biological contexts. It exhibits a logP value of 4.16, indicating its partition coefficient. The compound shows antioxidant activity (kDPPH < 2.0 M-1 s-1) and peroxidant properties (Ratio < 0.3). However, its inhibitory effect on 5-LO and LTB4 biosynthesis in bovine leukocytes is limited (IC50 > 30000.0 nM).
In cellular assays, Danthron displays antiproliferative activity (IC50 > 5000.0 nM) and cytotoxicity (LDH release = 170.0 MU) in HaCaT cells and induces differentiation at varying concentrations. Additionally, it enhances the proliferation of MCF-7 cell line and inhibits biofilm formation in Streptococcus mutans (MIC = 250.0 μg/mL; inhibition = 91.3% at 5 μg/mL). It also shows antibacterial activity against multiple bacterial strains with MIC values ranging from 25,000,000 nM to 100,000,000 nM and antiplatelet activity in rat platelet plasma.
Danthron exhibits cytotoxic activity against human Raji cells and inhibits EBV-early antigen activation with varying efficacies. It also shows antiangiogenic activity against BAEC cells and significant inhibitory activity on Trypanosoma cruzi trans-sialidase mutant.
The compound binds to calf thymus DNA, indicating hydrogen bonding and partial intercalation capabilities, and exhibits metal chelating activity, particularly with calcium ions. Its antiviral properties are observed against SARS-CoV-2 with some inhibition of virus-induced cytotoxicity though not very potent at tested concentrations.
Furthermore, Danthron inhibits human HDAC6 enzyme activity and MAO enzymes, showing selectivity for MAO-B over MAO-A. It also exhibits liver toxicity in moderate serum activity levels for ALT or AST but lacks significant toxicity in other liver conditions. Additionally, it shows activity in inhibiting monoamine oxidase enzymes and acid-mediated aggregation of the TTR V30M mutant, indicating its potential in various bioactivities and therapeutic applications..
Note: Summary generated by AI. Data source: ChEMBL 
生物活性
化学信息
储存&溶解度
| 产品描述 | Danthron (Antrapurol) is a natural product, regulates glucose, and lipid metabolism by activating AMPK. |
| 别名 | 丹蒽醌, Dantron, Chrysazin, Antrapurol, 1,8-二羟基蒽醌, 1,8-Dihydroxyanthraquinone |
| 分子量 | 240.21 |
| 分子式 | C14H8O4 |
| CAS No. | 117-10-2 |
| Smiles | OC1=CC=CC2=C1C(=O)C1=C(O)C=CC=C1C2=O |
| 密度 | 1.3032 g/cm3 (Estimated) |
| 存储 | keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| 溶解度信息 | Ethanol: < 1 mg/mL (insoluble or slightly soluble) H2O: < 1 mg/mL (insoluble or slightly soluble) DMSO: 4 mg/mL (16.65 mM), Sonication is recommended. | ||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||
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TCMIP相关数据
中药材来源及性味归经
所属中药方剂
| 中药材名称 | 中药材拉丁名 | 性 | 味 | 归经 |
|---|---|---|---|---|
| 金鸡纳 | Cinchona calisaya Weddell | 寒 | 苦 |
| 方剂名称 | 处方组成 | 剂型 | 处方来源 |
|---|---|---|---|
| 疟疾五神丹 | 姜半夏,川贝母,青皮,青蒿,金鸡纳 | 丸剂 | 《湿温时疫治疗法》引何廉臣方。 |
计算器
体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
剂量转换
对于不同动物的给药剂量换算，您也可以参考 更多
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