AS1949490

Name: AS1949490
Brand: TargetMol
SKU: T14327
Price: 413 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.94%

货号 T14327Cas号 1203680-76-5

AS1949490 是选择性SHIP-2抑制剂，其IC50=620 nM。它能够通过上调L6肌管GLUT1基因激活葡萄糖代谢。

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AS1949490

一键复制产品信息

很棒

纯度: 99.94%

货号 T14327Cas号 1203680-76-5

AS1949490 是选择性SHIP-2抑制剂，其IC50=620 nM。它能够通过上调L6肌管GLUT1基因激活葡萄糖代谢。

规格	价格	库存
1 mg	¥ 413	现货
5 mg	¥ 892	现货
10 mg	¥ 1,480	现货
25 mg	¥ 3,150	现货
50 mg	¥ 4,570	现货
100 mg	¥ 6,380	现货
200 mg	¥ 8,630	现货
1 mL x 10 mM (in DMSO)	¥ 745	现货

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纯度: 99.94%

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产品介绍

AS1949490 AI Summary

AS1949490 exhibits notable antidiabetic and antiviral activities, alongside significant toxicity in various mouse models. It demonstrates antidiabetic properties by improving glucose tolerance, increasing serum insulin levels, and reducing fasting plasma glucose levels. These effects are attributed to the inhibition of SHIP2 in Sprague-Dawley rat cortical neurons and mouse 3T3L1 cells. Regarding its antiviral activity, AS1949490 inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells with an inhibition rate of 103.13% at a concentration of 10 µM after 48 hours. However, it shows minimal inhibition of the SARS-CoV-2 3CL-Pro protease (3.147% inhibition at 20 µM) and low inhibition of virus-induced cytotoxicity in VERO-6 cells (-0.02% at 10 µM). AS1949490 also displays enzymatic inhibitory activity against the human HDAC6 enzyme, with 16.5% inhibition in one assay and 0.98% inhibition in another. The compound effectively inhibits the human SHIP2 catalytic domain phosphatase activity with an IC50 of 1500 nM and a Ki of 440 nM when expressed in Escherichia coli. However, notable toxic effects have been observed at a dose of 300 mg/kg administered twice daily for 12 to 13 days in mice, including changes in body weight, food intake, liver weight, and epididymal white adipose tissue weight..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	AS1949490 activated glucose metabolism via up-regulation of GLUT1 gene in L6 myotubes[1][2]. AS1949490 is a potent and selective SHIP-2 (SH2 domain-containing inositol 5′ phosphatase 2) inhibitor, with an IC50 of 620 nM.
靶点活性	SHIP2:620 nM

化学信息

分子量	371.88
分子式	C₂₀H₁₈ClNO₂S
CAS No.	1203680-76-5
Smiles	C[C@H](NC(=O)c1sccc1OCc1ccc(Cl)cc1)c1ccccc1
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 49 mg/mL (131.76 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.38 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6890 mL	13.4452 mL	26.8904 mL	134.4520 mL
5 mM	0.5378 mL	2.6890 mL	5.3781 mL	26.8904 mL
10 mM	0.2689 mL	1.3445 mL	2.6890 mL	13.4452 mL
20 mM	0.1345 mL	0.6723 mL	1.3445 mL	6.7226 mL
50 mM	0.0538 mL	0.2689 mL	0.5378 mL	2.6890 mL
100 mM	0.0269 mL	0.1345 mL	0.2689 mL	1.3445 mL