规格

价格

库存

数量

1 mg

¥ 1,480

现货

5 mg

¥ 2,980

现货

10 mg

¥ 4,480

现货

25 mg

¥ 6,930

现货

50 mg

¥ 9,330

现货

100 mg

¥ 12,600

现货

1 mL x 10 mM (in DMSO)

¥ 3,290

现货

生物活性

产品描述	CCR6 inhibitor 1 is an effective and selective inhibitor of CCR6 (IC50 of monkey and human CCR6 was 0.45 nM and 6 nM, respectively). CCR6 is associated with both autoimmune and non-autoimmune diseases, so CCR6 inhibitor 1 is useful for in vitro and in vivo pathophysiology studies as a small molecule inhibitor of CCR6.
靶点活性	CCR6 (monkey):0.45 nM, CCR7 (human):9400 nM, CCR6 (human):6 nM
体外活性	在人类CCR6转染的CHO细胞中，CCR6 inhibitor 1 显示出Gi信号抑制活性与细胞迁移抑制活性之间良好的相关性，能够有效抑制依赖CCR6的细胞迁移以及人类初代细胞中ERK磷酸化的增加[1]。

化学信息

分子量	504.52
分子式	C₂₄H₂₃F₃N₄O₃S
CAS No.	2437547-04-9
Smiles	NC(=O)c1cc(ccn1)-c1ccc(cc1)S(=O)(=O)[C@H]1CC[C@@H](CC1)Nc1ccc(cn1)C(F)(F)F
密度	1.391 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 112.5 mg/mL (222.98 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (7.93 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO