Iprodione demonstrates a broad range of biological activities across various assays and pathogens. It exhibits notable cytotoxicity against L-6 rat myoblasts with an IC50 value greater than 100,000 nM and shows inhibition of the Chagas Disease parasite Trypanosoma cruzi, with an IC50 value of 49,046 nM. In terms of cellular signaling, it acts as an agonist or antagonist in multiple pathways, including estrogen receptor alpha, peroxisome proliferator-activated receptors (PPAR) delta and gamma, antioxidant response element (ARE), and pregnane X receptor (PXR) with potencies ranging from 22,387.2 nM to 70,794.6 nM.
In agricultural applications, Iprodione exhibits potent fungicidal and antifungal activities against various pathogens. It shows effectiveness against Pestalotiopsis microspora and exhibits high inhibitory effects on pathogens affecting cucumber plants, such as Sclerotinia sclerotiorum and Ascochyta citrallina, with growth inhibition (GI) values up to 98.4%. It also demonstrates fungicidal activity against Ceratobasidium cereale, Rhizoctonia solani AG-1 IA, Alternaria solani, Passalora fulva, Botryotinia fuckeliana, Macrophomina phaseolina, Monilinia laxa, Bionectria ochroleuca, Diplodia mutila, Neofusicoccum luteum, and Mycogone perniciosa with varying EC50 and ED50 values, signifying its broad-spectrum antifungal properties. Notably, it reduces disease incidence in non-grafted melon plants when applied as a soil drench, controls cucumber gray mold disease effectively with preventive and curative foliar applications, and demonstrates significant activity in reducing pathogen incidence and lesion length in infected grapevines. These activities suggest that Iprodione has potential applications in both medical and agricultural fields for the control of various diseases and pathogens..
Note: Summary generated by AI. Data source: ChEMBL 