Name: 4E2RCat
Brand: TargetMol
SKU: T14044
Price: 527 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 527

现货

5 mg

¥ 1,250

现货

10 mg

¥ 1,870

现货

25 mg

¥ 3,170

现货

50 mg

¥ 4,470

现货

100 mg

¥ 5,910

现货

200 mg

¥ 7,970

现货

1 mL x 10 mM (in DMSO)

¥ 1,250

现货

产品介绍

生物活性

产品描述	4E2RCat is an inhibitor of eIF4E-eIF4G interaction (IC50 = 13.5 μM) and is capable of blocking coronavirus replication as monitored by viral protein expression and the production of infectious virus.
靶点活性	eIF4E-eIF4G:13.5 μM
体外活性	4E2RCat prevents the interaction between eIF4E (the cap-binding protein) and eIF4G (a large scaffolding protein), inhibiting cap-dependent translation. It significantly decreases human coronavirus 229E (HCoV-229E) replication, reducing the percentage of infected cells and intra- and extracellular infectious virus titers. 4E2RCat inhibits cap-dependent translation in a dose-dependent manner. 4E2RCat inhibits cap-dependent FF translation but not EMCV IRES-driven Ren translation. 4E2RCat inhibits coronavirus replication in a dose- and time-dependent manner[1].
体内活性	4E2RCat inhibits protein synthesis in vivo and it is not a consequence of increased cell death[1].

化学信息

分子量	455.93
分子式	C₂₂H₁₄ClNO₄S₂
CAS No.	432499-63-3
Smiles	OC(=O)c1cc(ccc1Cl)-c1ccc(\C=C2/SC(=S)N(Cc3ccccc3)C2=O)o1
密度	1.56 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 15.5 mg/mL (34 mM), Sonication and heating are recommended.

溶液配制表

DMSO

体内实验配液计算器