CB2R/FAAH modulator-3 (compound 27) is a modulator targeting at CB2R and FAAH. CB2R/FAAH modulator-3 acts as a CB2R agonist and FAAH inhibitor, the Ki values are 20.1 and 67.6 nM for CB2R and CB1R, respectively, and the IC50 value for FAAH is 3.4 μM. CB2R/FAAH modulator-3 has research value related to cancer, deleterious inflammatory cascades occurring in neurodegenerative diseases, and COVID-19 infection.

CB1:67.6 nM (Ki), CB2:20.1 nM (Ki)

CB2R/FAAH modulator-3（10 μM）能够在未刺激的单核细胞和巨噬细胞中降低炎症性细胞因子TNFα、IFN-γ、IL-1β和IL6的产生[1]。