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CPI1189

Name: CPI1189
Brand: TargetMol
SKU: T3561
Price: 169 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.51%

货号 T3561Cas号 183619-38-7

别名 REN-1189, CPI-1189, CPI 1189

CPI1189 (REN-1189) 是 TNF-α 释放抑制剂，具有神经保护作用及抗氧化作用。它可用于研究 HIV 相关神经毒性，具有成为 HIV 相关 CNS 疾病患者神经保护治疗药物的潜能。

为众多的药物研发团队赋能，

让新药发现更简单！

CPI1189

一键复制产品信息

很棒

纯度: 99.51%

货号 T3561 别名 REN-1189, CPI-1189, CPI 1189Cas号 183619-38-7

规格	价格	库存
5 mg	¥ 169	现货
10 mg	¥ 259	现货
25 mg	¥ 500	现货
50 mg	¥ 708	现货
100 mg	¥ 1,060	现货
500 mg	¥ 2,580	现货
1 mL x 10 mM (in DMSO)	¥ 187	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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产品介绍

CPI1189 AI Summary

CPI1189 exhibits antiviral activity against SARS-CoV-2 by inhibiting its induced cytotoxicity in both Caco-2 and VERO-6 cells at a concentration of 10 µM after 48 hours. In Caco-2 cells, the inhibition rate is 4.9%, while in VERO-6 cells, the inhibition effects range from -0.06% to -0.18%. Additionally, this compound shows SARS-CoV-2 3CL-Pro protease inhibition with inhibition percentages of 11.56% and 14.49% at 20 µM, as determined by a FRET assay using a peptide substrate. In terms of its effect on human HDAC6, CPI1189 demonstrates an inhibition rate of 9.15% with a commercial peptide substrate, though it shows negligible inhibition (-3.78%) with a custom peptide substrate. The IC50 value for this compound is greater than 20,000 nM, suggesting a moderate to weak inhibitory effect..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	CPI1189 (REN-1189) is a TNF-a release inhibitor potentially for the treatment of sciatica and postherpetic neuralgia.
别名	REN-1189, CPI-1189, CPI 1189

化学信息

分子量	234.29
分子式	C₁₃H₁₈N₂O₂
CAS No.	183619-38-7
Smiles	CC(=O)Nc1ccc(cc1)C(=O)NC(C)(C)C
密度	1.102 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (213.41 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.54 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.2682 mL	21.3411 mL	42.6821 mL	213.4107 mL
5 mM	0.8536 mL	4.2682 mL	8.5364 mL	42.6821 mL
10 mM	0.4268 mL	2.1341 mL	4.2682 mL	21.3411 mL
20 mM	0.2134 mL	1.0671 mL	2.1341 mL	10.6705 mL
50 mM	0.0854 mL	0.4268 mL	0.8536 mL	4.2682 mL
100 mM	0.0427 mL	0.2134 mL	0.4268 mL	2.1341 mL