Anti-NAIP Antibody (4Y60)

Name: Anti-NAIP Antibody (4Y60)
Brand: TargetMol
SKU: TMAH-00802
Rating: 4.5 (1 reviews)

还可以

产品编号 TMAH-00802

Anti-NAIP Antibody (4Y60) 是一种抗体，靶向 NAIP。Anti-NAIP Antibody (4Y60) 可用于 ELISA, IHC。

Anti-NAIP Antibody (4Y60)

还可以

产品编号 TMAH-00802

Anti-NAIP Antibody (4Y60) 是一种抗体，靶向 NAIP。Anti-NAIP Antibody (4Y60) 可用于 ELISA, IHC。

规格	价格	库存	数量
50 μL	¥ 1,305	5日内发货
100 μL	¥ 2,180	5日内发货

大包装 & 定制

加入购物车

TargetMol 的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

联系我们获取更多批次信息

资源下载

产品操作手册

产品介绍

生物活性

产品描述	Anti-NAIP Antibody (4Y60) is an antibody targeting NAIP. Anti-NAIP Antibody (4Y60) can be used in ELISA, IHC.
Ig Type	Rabbit IgG
克隆号	4Y60
交叉反应	Human
验证活性	IHC image of TMAH-00802 diluted at 1:80 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.48% DAB.
应用	ELISA, IHC
推荐剂量	IHC:1:50-1:200.
抗体种类	Monoclonal
构建方式	Recombinant Antibody
纯化方式	Affinity-chromatography
性状	Liquid
缓冲液	Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景	Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy. Acts as a sensor component of the NLRC4 inflammasome that specifically recognizes and binds needle protein CprI from pathogenic bacteria C.violaceum. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria such as C.violaceum and L.pneumophila.