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ML240

Name: ML240
Brand: TargetMol
SKU: T3535
Price: 269 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.73%

货号 T3535Cas号 1346527-98-7

ML240 是一种选择性的 ATP 竞争性 p97 抑制剂，IC50值为 100 nM。

为众多的药物研发团队赋能，

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ML240

一键复制产品信息

很棒

纯度: 99.73%

货号 T3535Cas号 1346527-98-7

ML240 是一种选择性的 ATP 竞争性 p97 抑制剂，IC50值为 100 nM。

规格	价格	库存
1 mg	¥ 269	现货
2 mg	¥ 383	现货
5 mg	¥ 629	现货
10 mg	¥ 986	现货
25 mg	¥ 2,090	现货
50 mg	¥ 3,280	现货
100 mg	¥ 4,680	现货
200 mg	¥ 6,530	现货
1 mL x 10 mM (in DMSO)	¥ 692	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.73%

颜色: 白色

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

ML240 AI Summary

ML240 exhibits multiple bioactivities. It inhibits human p97 ATPase with an IC50 of 815.0 nM, indicating its potential as a potent ATPase inhibitor. It displays cytotoxicity against human A549 cells with an IC50 of 3260.0 nM and against HepG2 cells with an IC50 of 9600.0 nM. In A549 cells, it leads to the accumulation of K48 poly-ubiquitinated proteins and CHOP poly-ubiquitinated proteins, with IC50 values of 6140.0 nM and 6610.0 nM respectively, implicating its role in protein degradation pathways. The compound also demonstrates antiviral activity, inhibiting SARS-CoV-2 in the Vero E6 cell line with an IC50 of approximately 476.43 nM. It shows good selectivity for viral inhibition over cytotoxicity, with an AUC ratio of 0.787. Additionally, the compound inhibits the p97 enzyme activity with an IC50 of 110.0 nM in a biomol green assay and shows reversible inhibition of His-tagged p97 enzyme and its C552A mutant, with 82.0% activity for wild-type p97 and complete inhibition for the C552A mutant at 100.0%. In testing against SARS-CoV-2 3CL-Pro protease at 20 µM, it shows an inhibition percentage of -7.72%. When tested on SARS-CoV-2 induced cytotoxicity in Vero-6 cells at 10 µM, it exhibits an inhibition of -0.16% after 48 hours. The compound has a short half-life of 0.1167 hours in mouse liver microsomes, indicating rapid metabolism, and a low aqueous solubility of less than 1.0 µg/mL, which may affect its formulation and delivery in aqueous solutions..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	ML240 is a selective, ATP-competitive p97 inhibitor.
靶点活性	p97:100 nM.

化学信息

分子量	396.44
分子式	C₂₃H₂₀N₆O
CAS No.	1346527-98-7
Smiles	COc1cccc2c(NCc3ccccc3)nc(nc12)-n1c(N)nc2ccccc12
密度	1.35 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (126.12 mM), Sonication is recommended.

体内实验配方

10% DMSO+90% Corn Oil: 2.5 mg/mL (6.31 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5224 mL	12.6122 mL	25.2245 mL	126.1225 mL
5 mM	0.5045 mL	2.5224 mL	5.0449 mL	25.2245 mL
10 mM	0.2522 mL	1.2612 mL	2.5224 mL	12.6122 mL
20 mM	0.1261 mL	0.6306 mL	1.2612 mL	6.3061 mL
50 mM	0.0504 mL	0.2522 mL	0.5045 mL	2.5224 mL
100 mM	0.0252 mL	0.1261 mL	0.2522 mL	1.2612 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。