规格

价格

库存

数量

5 mg

¥ 987

35日内发货

10 mg

¥ 1,970

35日内发货

50 mg

¥ 8,160

35日内发货

100 mg

¥ 14,200

35日内发货

生物活性

产品描述	Ro 48-8071 is a small-molecule inhibitor of oxidosqualene cyclase (OSC), a key enzyme in the cholesterol biosynthesis pathway. In murine models, oral administration at 20 mg/day/kg body weight achieves a rapid and sustained >50% inhibition of cholesterol synthesis in the small intestine, while hepatic synthesis rebounds to above baseline within seven days. The compound also suppresses hormone-dependent breast cancer cell proliferation at nanomolar IC₅₀ concentrations for OSC, degrading ERα and inducing anti-proliferative ERβ protein expression. Research applications include studying intestinal cholesterol regulation and investigating estrogen and androgen receptor transcriptional activity in cancer cell models.
靶点活性 (IC₅₀)	Oxidosqualene cyclase:≈6.5 nM
体外活性	方法：在人体肝微粒体和完整HepG2细胞中评价Ro 48-8071对氧化鲨烯环化酶的抑制作用。结果：Ro 48-8071抑制微粒体和细胞氧化鲨烯环化酶的IC₅₀分别约为6.5和1.5 nM，并降低胆固醇合成。^[1]
体内活性	方法：在仓鼠、松鼠猴和小型猪中评价Ro 48-8071。结果：在仓鼠中，约150 μg/kg口服处理使血浆LDL胆固醇降低约40%，但未降低HDL胆固醇，也未产生明确肝毒性。^[1]
别名	Ro48-8071

化学信息

分子量	448.37
分子式	C₂₃H₂₇BrFNO₂
CAS No.	161582-11-2
Smiles	O=C(C1=CC=C(Br)C=C1)C2=CC=C(OCCCCCCN(C)CC=C)C=C2F
密度	1.235g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 7.3 mg/mL (16.28 mM), Sonication is recommended.

溶液配制表

DMSO

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

Ro 48-8071