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(E)-AG 99

Name: (E)-AG 99
Brand: TargetMol
SKU: T5155
Price: 119 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.23%

货号 T5155Cas号 122520-85-8

别名 Tyrphostin 46, AG 99, (E)-Tyrphostin AG 99, (E)-Tyrphostin 46

(E)-AG 99 ((E)-Tyrphostin AG 99) 是一种 EGFR 抑制剂。

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(E)-AG 99

一键复制产品信息

很棒

纯度: 99.23%

货号 T5155 别名 Tyrphostin 46, AG 99, (E)-Tyrphostin AG 99, (E)-Tyrphostin 46Cas号 122520-85-8

(E)-AG 99 ((E)-Tyrphostin AG 99) 是一种 EGFR 抑制剂。

规格	价格	库存
1 mg	¥ 119	现货
5 mg	¥ 247	现货
10 mg	¥ 359	现货
25 mg	¥ 523	现货
50 mg	¥ 787	现货
100 mg	¥ 1,230	现货
200 mg	¥ 1,820	现货
1 mL x 10 mM (in DMSO)	¥ 272	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.23%

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COA LCMS HNMR 产品操作手册

产品介绍

(E)-AG 99 AI Summary

(E)-AG 99 exhibits multiple bioactivities across a variety of targets. It acts as an inhibitor of the epidermal growth factor receptor (EGFR) with IC50 values ranging from 4,000.0 nM to 20,000.0 nM, depending on the specific assay conditions and targets (e.g., phosphorylation of exogenous substrates or autophosphorylation). Additionally, it shows inhibitory activity against Lck kinase with an IC50 of 22,000.0 nM, and against HER-2 with an IC50 of 6,456.54 nM. The compound indicates low potency against HIV-1 integrase, with an IC50 value greater than 100,000.0 nM, and demonstrates weak inhibition of dynamin1 GTPase with IC50 greater than 300,000.0 nM. (E)-AG 99 also shows antiviral properties against SARS-CoV-2 by inhibiting its 3CL-Pro protease with 20.27% inhibition at 20 µM and against SARS-CoV-2 induced cytotoxicity in cell cultures. Furthermore, it exhibits cytotoxicity against mouse B16F10 cells and modulates activity in other targets such as human TREK1 channels and HDAC6 enzymes. It also displays antinociceptive effects in CD1 mice models. Overall, (E)-AG 99 presents significant, albeit varied, bioactivity which highlights its potential versatility in therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	(E)-AG 99 ((E)-Tyrphostin AG 99) is an inhibitor of EGFR kinase (IC50: 10 μM in the human epidermoid carcinoma cell line A431).
靶点活性	EGFR kinase:10 µM
别名	Tyrphostin 46, AG 99, (E)-Tyrphostin AG 99, (E)-Tyrphostin 46

化学信息

分子量	204.18
分子式	C₁₀H₈N₂O₃
CAS No.	122520-85-8
Smiles	NC(=O)C(=C\c1ccc(O)c(O)c1)\C#N
密度	1.482g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: Insoluble

Ethanol: 1 mg/mL (4.9 mM), Sonication is recommended.

DMSO: 50 mg/mL (244.88 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.8 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.8976 mL	24.4882 mL	48.9764 mL	244.8820 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.9795 mL	4.8976 mL	9.7953 mL	48.9764 mL
10 mM	0.4898 mL	2.4488 mL	4.8976 mL	24.4882 mL
20 mM	0.2449 mL	1.2244 mL	2.4488 mL	12.2441 mL
50 mM	0.0980 mL	0.4898 mL	0.9795 mL	4.8976 mL
100 mM	0.0490 mL	0.2449 mL	0.4898 mL	2.4488 mL