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Frentizole

Name: Frentizole
Brand: TargetMol
SKU: T7527
Price: 127 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 夫仑替唑

货号 T7527Cas号 26130-02-9 一键复制产品信息纯度: 99.82%

很棒

Frentizole 是一种 FDA 批准的免疫抑制剂，是一种新型 Aβ-ABAD 相互作用抑制剂。

Frentizole

一键复制产品信息

很棒

纯度: 99.82%

货号 T7527Cas号 26130-02-9

别名 夫仑替唑

Frentizole 是一种 FDA 批准的免疫抑制剂，是一种新型 Aβ-ABAD 相互作用抑制剂。

为众多的药物研发团队赋能，

让新药发现更简单！

规格	价格	库存
2 mg	¥ 127	现货
5 mg	¥ 209	现货
10 mg	¥ 330	现货
25 mg	¥ 541	现货
50 mg	¥ 819	现货
100 mg	¥ 1,210	现货
200 mg	¥ 1,790	现货
1 mL x 10 mM (in DMSO)	¥ 230	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.82%

颜色: 白色

性状: Solid

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资源下载:

COA LCMS HNMR 产品操作手册

产品介绍

Frentizole AI Summary

Frentizole exhibits a diverse range of bioactivities, demonstrating significant suppressive activity on delayed type hypersensitivity (DTH) without affecting humoral immunity in mice at an oral dose of 50 mg/kg. It shows an increase in ear thickness by 3.5 1/100mm and an inhibition rate of 42.6%. As an inhibitor of the beta amyloid-ABAD interaction, it has an IC50 value of 200000.0 nM. Additionally, this compound modulates various biological processes, including gene expression, splicing, and promoter activation, and shows activity in multiple assays involving lamin A splicing, NF-kB expression, miRNA activation, tau fibril alteration, and histone lysine methyltransferase inhibition, among others. Despite its broad bioactivity, Frentizole is associated with moderate liver toxicity, with hepatotoxicity occurring in 70% of clinical trials, and low incidences of acute liver toxicity and cirrhosis (2% and 0%, respectively). No severe liver complications such as choleostasis, granulomatous hepatitis, or steatosis were observed. In cytotoxicity assays against CHOK1 cells, Frentizole has an LC50 value of 31000.0 nM. It shows minimal inhibition of Dyrk1B and weak inhibition of Dyrk1A. In antiviral activity assays, it inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells and VERO-6 cells at 10 µM with varying inhibition percentages. The compound also inhibits the SARS-CoV-2 3CL-Pro protease, with inhibition percentages of 30.22% and 20.99% at 20 µM. Furthermore, Frentizole displays potent inhibition of human HDAC6 in enzymatic assays, with inhibition percentages ranging from 58.18% to 108.65% and an IC50 value of 592.3 nM, indicating effective enzyme inhibition at a low concentration..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Frentizole, an immunosuppressive agent, is an inhibitor of the Aβ-ABAD interaction
别名	夫仑替唑

化学信息

分子量	299.35
分子式	C₁₅H₁₃N₃O₂S
CAS No.	26130-02-9
Smiles	COc1ccc2nc(NC(=O)Nc3ccccc3)sc2c1
密度	1.42g/cm3

储存&溶解度

存储

溶解度信息

DMSO: 3 mg/mL (10.02 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3.34 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3406 mL	16.7029 mL	33.4057 mL	167.0286 mL
5 mM	0.6681 mL	3.3406 mL	6.6811 mL	33.4057 mL
10 mM	0.3341 mL	1.6703 mL	3.3406 mL	16.7029 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。