规格

价格

库存

数量

1 mg

¥ 543

现货

2 mg

¥ 789

现货

5 mg

¥ 1,820

现货

10 mg

¥ 2,930

现货

25 mg

¥ 4,870

现货

50 mg

¥ 6,950

现货

100 mg

¥ 9,390

现货

500 mg

¥ 18,800

现货

1 mL x 10 mM (in DMSO)

¥ 1,930

现货

生物活性

产品描述	Tenovin-6 is a p53 transcriptional activity agonist.
靶点活性	SIRT2:10 μM, SIRT1:21 μM, SIRT3:67 μM
体内活性	Tenovins are active on mammalian cells at one-digit micromolar concentrations and decrease tumor growth in vivo as single agents. Tenovin-6 (50 mg/kg, i.p.) inhibits the growth of tumor in mice[1].
激酶实验	Assays are carried out using purified components in the Fluor de Lys Fluorescent Assay Systems. Relevant FdL substrates are used at 7 μM and NAD+ at 1 mM. Tenovins are solubilized in DMSO with the final DSMO concentration in the reaction being less than 0.25%. For SirT1 and HDAC8, one unit of enzyme is used per reaction, and for SirT2 and SirT3, five units is used per reaction. Reactions are carried out at 37°C for 1 hr.
细胞实验	The MTS assay is used to evaluate cell viability. UM cells are seeded into each well of 96-well plates (5,000 cells/well) and treated the next day with control or Tenovin-6 in an increasing concentrations from 0 to 20?μM for 68?h, and then MTS is added at 20?μL/well to be read at a wave length of 490?nm, the IC50 is determined by curve fitting of the sigmoidal dose-response curve.
别名	Tenovin 6

化学信息

分子量	454.63
分子式	C₂₅H₃₄N₄O₂S
CAS No.	1011557-82-6
Smiles	CN(C)CCCCC(=O)Nc1ccc(NC(=S)NC(=O)c2ccc(cc2)C(C)(C)C)cc1
密度	1.171 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 91 mg/mL (200.16 mM), Sonication is recommended.

H2O: 90 mg/mL (197.96 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.26 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1996 mL	10.9980 mL	21.9959 mL	109.9795 mL
5 mM	0.4399 mL	2.1996 mL	4.3992 mL	21.9959 mL
10 mM	0.2200 mL	1.0998 mL	2.1996 mL	10.9980 mL
20 mM	0.1100 mL	0.5499 mL	1.0998 mL	5.4990 mL
50 mM	0.0440 mL	0.2200 mL	0.4399 mL	2.1996 mL
100 mM	0.0220 mL	0.1100 mL	0.2200 mL	1.0998 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

Tenovin-6

Tenovin-6

产品介绍

引用文献

计算器

体内实验配液计算器

剂量转换

关键词

Tenovin-6

Tenovin-6

Tenovin-6 相关产品

产品介绍

引用文献

计算器

体内实验配液计算器

剂量转换

关键词