Geraniin

Name: Geraniin
Brand: TargetMol
SKU: T6S2099
Price: 282 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.49%

货号 T6S2099Cas号 60976-49-0

别名 老鹳草素

Geraniin 是一种肿瘤坏死因子α释放抑制剂，其IC50值为 43 μM，具有抗肿瘤、抗炎和抗高血糖活性。

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Geraniin

一键复制产品信息

很棒

纯度: 99.49%

货号 T6S2099 别名 老鹳草素Cas号 60976-49-0

Geraniin 是一种肿瘤坏死因子α释放抑制剂，其IC50值为 43 μM，具有抗肿瘤、抗炎和抗高血糖活性。

规格	价格	库存
1 mg	¥ 282	现货
5 mg	¥ 822	现货
10 mg	¥ 1,450	现货
25 mg	¥ 2,450	现货
50 mg	¥ 3,630	现货
100 mg	¥ 5,170	现货
1 mL x 10 mM (in DMSO)	¥ 1,520	现货

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TargetMol 的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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产品介绍

生物活性

产品描述	1. Geraniin has a protective effect against OVX-induced rat osteoporosis. 2. Geraniin has cytotoxic activity towards cancer cells in vitro and in vivo. 3. Geraniin exerts inhibitory effects on osteoclast differentiation in vitro and suppresses Ti particle-induced osteolysis in vivo, is a potential natural compound for the treatment of wear particle induced osteolysis in prostheses failure. 4. Geraniin has anti-oxidant activity, induces Nrf2-mediated expression of antioxidant enzymes HO-1 and NQO1, presumably via PI3K/AKT and ERK1/2 signaling pathways, thereby protecting cells from H2O2-induced oxidative cell death. 5. Geraniin presents radioprotective effects by regulating DNA damage on splenocytes, exerting immunostimulatory capacities and inhibiting apoptosis of radiosensitive immune cells and jejunal crypt cells.
靶点活性	TNF-α:43 μM.
别名	老鹳草素

化学信息

分子量	952.64
分子式	C₄₁H₂₈O₂₇
CAS No.	60976-49-0
Smiles	Oc1cc(cc(O)c1O)C(=O)O[C@@H]1O[C@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(O)c(O)c(O)cc3C(=O)O[C@@H]3[C@H]2OC(=O)C2=CC(=O)C4(O)Oc5c(O)c(O)cc(c5C2C4(O)O)C(=O)O[C@H]13
密度	2.25g/cm3

储存&溶解度

存储

keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

Ethanol: Soluble

Pyridine, Methanol, etc.: Soluble

DMSO: 247.5 mg/mL (259.8 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (3.46 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0497 mL	5.2486 mL	10.4971 mL	52.4857 mL
5 mM	0.2099 mL	1.0497 mL	2.0994 mL	10.4971 mL
10 mM	0.1050 mL	0.5249 mL	1.0497 mL	5.2486 mL
20 mM	0.0525 mL	0.2624 mL	0.5249 mL	2.6243 mL
50 mM	0.0210 mL	0.1050 mL	0.2099 mL	1.0497 mL
100 mM	0.0105 mL	0.0525 mL	0.1050 mL	0.5249 mL