Name: Lactacystin
Brand: TargetMol
SKU: T15702
Price: 1230 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

50 μg

¥ 1,230

现货

100 μg

¥ 1,990

现货

1 mg

¥ 6,680

现货

生物活性

产品描述	Lactacystin is an orally active, irreversible, and cell-permeable proteasome inhibitor (IC50 = 4.8 μM) that also inhibits the lysosomal enzyme cathepsin A. It induces apoptosis and cell cycle arrest, possesses anticancer, antiviral, and antioxidant activities, can penetrate the blood-brain barrier, and is commonly used in the construction of Parkinson’s disease and dementia models.
靶点活性	Proteasome:4.8 μM
体外活性	方法：Lactacystin（2.5–10 μg/ml，48小时）处理 RA 分化的 SH-SY5Y 细胞，以选择用于 celastrol 研究的有效浓度。结果：Lactacystin浓度为 10 μg/ml （26.4 μM） SH-SY5Y 细胞活力降低 40-50%。[3]
体内活性	方法：Lactacystin（5 μg/2 μl）单侧给药到大鼠左侧 SNc 中，研究对大鼠体重的影响。结果：Lactacystin可以使大鼠体重减少。[3]
别名	蛋白酶体抑制剂

化学信息

分子量	376.43
分子式	C₁₅H₂₄N₂O₇S
CAS No.	133343-34-7
Smiles	C(SC[C@H](NC(C)=O)C(O)=O)(=O)[C@@]1([C@H](C(C)C)O)[C@@H](O)[C@@H](C)C(=O)N1
密度	1.367 g/cm3

储存&溶解度

存储

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 18 mg/mL (47.82 mM), Sonication and heating are recommended.

溶液配制表

DMSO

Lactacystin