Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Idoxuridine hydrate (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) is a competitive inhibitor of phosphorylases. As an iodinated thymidine analogue, it effectively inhibits DNA polymerase and hinders viral replication, making it useful in the treatment of viral eye infections such as herpes simplex keratitis. Against feline herpesvirus, Idoxuridine has been found to have an IC50 value of 4.3 μM [1].
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 14,900 | 6-8周 | ||
50 mg | ¥ 19,420 | 6-8周 | ||
100 mg | ¥ 24,625 | 6-8周 |
Idoxuridine hydrate 的其他形式现货产品:
产品描述 | Idoxuridine hydrate (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) is a competitive inhibitor of phosphorylases. As an iodinated thymidine analogue, it effectively inhibits DNA polymerase and hinders viral replication, making it useful in the treatment of viral eye infections such as herpes simplex keratitis. Against feline herpesvirus, Idoxuridine has been found to have an IC50 value of 4.3 μM [1]. |
体外活性 | Idoxuridine (2-10 μM, 72 hours) hydrate has the IC 50 value of 4.3 μM of antiviral [1]. Cell Proliferation Assay [1] Cell Line: Crandell-Reese feline kidney (CRFK) cells Concentration: 2-10 μM Incubation Time: 72 hours Result: Showed the IC 50 value of 4.3 μM. Cell Cytotoxicity Assay [1] Cell Line: Crandell-Reese feline kidney (CRFK) cells Concentration: 5-50 μM Incubation Time: 72 hours Result: Reduced by 10.8% relatively in CRFK cells. |
体内活性 | Idoxuridine (intraperitoneal injection, 50-200 mg/kg, 3 times, 3 hours interval) hydrate can stimulate the production of hemolysin plaque-forming cells (HPFC) to sheep red blood cells (SRBC) in C3HeB/FeJ female and male mice and A/J male mice [2]. Animal Model: C3HeB/FeJ female and male mice and A/J male mice, aged 2 to 4 months [2] Dosage: 50-200 mg/kg Administration: Intraperitoneal injection, 3 times, 3 hours interval Result: Stimulated the production of hemolysin plaque-forming cells (HPFC) to sheep red blood cells (SRBC) in the dose range of 50-200 mg/kg. |
分子量 | 372.115 |
分子式 | C9H13IN2O6 |
CAS No. | 17140-71-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Idoxuridine hydrate 17140-71-5 Inhibitor inhibitor inhibit