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Sulfisoxazole

Name: Sulfisoxazole
Brand: TargetMol
SKU: T0750
Price: 178 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.98%

货号 T0750Cas号 127-69-5

别名 磺胺异恶唑, 磺胺二甲异唑, Sulfafurazole, NU-445

Sulfisoxazole (Sulfafurazole) 是一种内皮素受体拮抗剂，是磺胺类抗生素。它靶向内皮素受体 A，抑制乳腺癌外显子释放。

Sulfisoxazole

一键复制产品信息

很棒

纯度: 99.98%

货号 T0750 别名 磺胺异恶唑, 磺胺二甲异唑, Sulfafurazole, NU-445Cas号 127-69-5

Sulfisoxazole (Sulfafurazole) 是一种内皮素受体拮抗剂，是磺胺类抗生素。它靶向内皮素受体 A，抑制乳腺癌外显子释放。

规格	价格	库存
50 mg	¥ 178	现货
100 mg	¥ 247	现货
200 mg	¥ 329	现货
500 mg	¥ 496	现货
1 g	¥ 723	现货
1 mL x 10 mM (in DMSO)	¥ 272	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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常见问题解答

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纯度: 99.98%

颜色: 白色

性状: Solid

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COA HPLC HNMR LCMS 产品操作手册

产品介绍

Sulfisoxazole AI Summary

Sulfisoxazole exhibits multifaceted bioactivity and pharmacokinetic properties, making it a significant compound for research. It shows potent inhibition of the Endothelin A receptor with an IC50 ranging from 780.0 nM to 9000.0 nM, indicating its strong interaction with this receptor in various systems, including rat aortic smooth muscle cells and human cells. Its binding affinity is much lower for the Endothelin B receptor, with an IC50 of 24000.0 nM. Pharmacokinetically, Sulfisoxazole has high oral bioavailability (>80%) and significant plasma protein binding in humans (91.28%), dogs (86.59%), and rats (98.47%). It demonstrates moderate clearance rates and distribution, with a total clearance of 0.3 mL.min-1.kg-1 and a volume of distribution at steady state of 0.17 L.kg-1. Its physicochemical properties include a logD6.5 value of -0.5 and a pKa of 5.0. Additionally, Sulfisoxazole exhibits bioactivity as an inhibitor of the Menin-MLL interaction, Thyroid Stimulating Hormone Receptor, Cytochrome P450 2C19, and various other targets. It shows antimicrobial activity against bacteria like Escherichia coli and Staphylococcus epidermidis, and antifungal activity against Aspergillus fumigatus, with MIC values indicating broad-spectrum bioactivity. Despite some liver toxicity and moderate liver clearance rates, it demonstrates low intrinsic clearance rates in rat hepatocytes and human liver microsomes, suggesting slow metabolism. Sulfisoxazole also shows antiviral activity against SARS-CoV-2, albeit with limited effectiveness according to various assays, including cytotoxicity and 3CL-Pro protease inhibition. Furthermore, it has been identified to inhibit the Bile Salt Export Pump (BSEP), though at high IC50 values (>135000.0 nM), indicating weak inhibition. Overall, Sulfisoxazole’s broad bioactivity profile, significant pharmacokinetic properties, and multi-target inhibition suggest its potential application in various therapeutic areas, albeit with caution due to its hepatotoxicity and moderate liver toxicity..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Sulfisoxazole (Sulfafurazole) is a short-acting sulfonamide antibacterial with activity against a wide range of gram-negative and gram-positive organisms.Sulfisoxazole inhibits breast cancer exosome release by targeting endothelin receptor A.
靶点活性	ETA:0.60 microM, ETB:22 microM
别名	磺胺异恶唑, 磺胺二甲异唑, Sulfafurazole, NU-445

化学信息

分子量	267.30
分子式	C₁₁H₁₃N₃O₃S
CAS No.	127-69-5
Smiles	CC1=NOC(NS(=O)(=O)C2=CC=C(N)C=C2)=C1C
密度	1.411g/cm3

储存&溶解度

存储

溶解度信息

DMSO: 250 mg/mL (935.28 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.48 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7411 mL	18.7056 mL	37.4111 mL	187.0557 mL
5 mM	0.7482 mL	3.7411 mL	7.4822 mL	37.4111 mL
10 mM	0.3741 mL	1.8706 mL	3.7411 mL	18.7056 mL
20 mM	0.1871 mL	0.9353 mL	1.8706 mL	9.3528 mL
50 mM	0.0748 mL	0.3741 mL	0.7482 mL	3.7411 mL
100 mM	0.0374 mL	0.1871 mL	0.3741 mL	1.8706 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Sulfisoxazole NU445 NU 445 Inhibitor inhibit EndothelinReceptor Endothelin Receptor DHPS breast cancer Bacterial Antibiotic

Sulfisoxazole

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体内实验配液计算器

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