Powder: -20°C for 3 years | In solvent: -80°C for 1 year
P32/98 hemifumarate 为二肽基肽酶 IV (DPP4) 抑制剂,可在Zucker糖尿病大鼠模型中改善葡萄糖耐量、提高胰岛素敏感性及增强β细胞反应性,具有预防2型糖尿病的潜力。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 859 | 现货 | ||
5 mg | ¥ 2,130 | 现货 | ||
10 mg | ¥ 3,190 | 现货 | ||
25 mg | ¥ 5,120 | 现货 | ||
50 mg | ¥ 6,910 | 现货 | ||
100 mg | ¥ 9,490 | 现货 | ||
500 mg | ¥ 18,800 | 现货 |
产品描述 | P32/98 hemifumarateis a potent inhibitor of dipeptidyl peptidase IV with a K i value of 130 nM. P32/98 hemifumarate improves glucose tolerance, insulin sensitivity and β-cell responsiveness in fatty Zucker rat model. P32/98 has the potential to prevent type 2 diabetes [1] [2] [3]. |
体外活性 | Glucagon-like peptide 1(GLP-1) is secreted into the circulation after food intake. GLP-1 acts function of stimulation of glucose dependent insulin secretion and induction of satiety feelings, and DPPIV is the major renal catabolic pathway for GLP-1 in vivo [2]. P32/98 hemifumarate, together with 200 pM GLP-1, (10 μM; 3 h) shows no significant inhibition of sodium re-absorption in porcine proximal tubular cells [2]. P32/98 hemifumarate (10 μM; 96 h) does not influence the mRNA expression of GLP-1R, DPPIV, Na + /H + exchanger isoform 3 (NHE3), sodium-dependent glucose transporter slc5a1, slc5a2 (SGLT1, 2) [2]. Cell Cytotoxicity Assay [2] Cell Line: Porcine proximal tubular cells Concentration: 10 μM Incubation Time: 96 hours Result: Showed no toxic. |
体内活性 | Long-time treatment of P32/98 hemifumarate (25 mg/kg; i.g.; once daily) significantly improves the glucose tolerance in Zucker diabetic fatty rats, a model of IGT (impaired glucose tolerance) [3]. Animal Model: Zucker diabetic fatty rat [3] Dosage: 25 mg/kg Administration: Oral gavage; once daily Result: Significantly improved the glucose tolerance in Zucker diabetic fatty rats. |
分子量 | 520.7 |
分子式 | C22H40N4O6S2 |
CAS No. | 251572-86-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
P32/98 (hemifumarate) 251572-86-8 P32/98 Inhibitor inhibitor inhibit