Cyclopiazonic acid

Name: Cyclopiazonic acid
Brand: TargetMol
SKU: T15027
Price: 497 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.80%

货号 T15027Cas号 18172-33-3

别名 环匹阿尼酸, 环二氮酸

Cyclopiazonic acid 是一种神经毒性次级代谢产物 (SM)，源于A. flavus，是一种纳摩尔内质网钙 ATP 酶抑制剂 (Ca2+ATPase; SERCA)，是植物细胞死亡的有效诱导剂。

Cyclopiazonic acid

一键复制产品信息

很棒

纯度: 99.80%

货号 T15027 别名 环匹阿尼酸, 环二氮酸Cas号 18172-33-3

Cyclopiazonic acid 是一种神经毒性次级代谢产物 (SM)，源于A. flavus，是一种纳摩尔内质网钙 ATP 酶抑制剂 (Ca2+ATPase; SERCA)，是植物细胞死亡的有效诱导剂。

规格	价格	库存
1 mg	¥ 497	现货
5 mg	¥ 1,230	现货
10 mg	¥ 1,990	现货
1 mL x 10 mM (in DMSO)	¥ 1,360	现货

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COA HNMR LCMS 产品操作手册

产品介绍

Cyclopiazonic acid AI Summary

Cyclopiazonic acid exhibits a diverse range of bioactivities, including modulation of autophagy, inhibition of key enzymes and proteins, as well as antiviral and antimalarial activities. It induces light chain 3-GFP levels and modulates autophagosome vesicle properties in human H4 cells, suggesting its influence on autophagic processes and vesicle dynamics. The compound also enhances long-lived protein degradation, indicating a role in cellular turnover mechanisms. Toxicity in rats shows an LC50 value of 30.0 mg kg-1. It inhibits the ATPase activity of SERCA in rabbit hind leg tissue microsomes with an IC50 value of 120.0 nM and shows antispasmodic activity in the guinea pig ileum, inhibiting acetylcholine-induced contraction at 10 µM with a 52.3% activity level. Against Plasmodium falciparum, including NITD609-resistant clones, it has an IC50 range of 3240.0 to 4160.0 nM and for strains FcB1 and 3D7, IC50 values of 4900.0 nM and 8800.0 nM, respectively. It exhibits antiviral activity against SARS-CoV-2 in various cell lines and inhibits the SARS-CoV-2 3CL-Pro protease. Additionally, it shows inhibitory activity on electric eel AChE, horse BChE, and human HDAC6 enzyme. The compound also targets a spectrum of other biological entities, including Tau fibril formation, Histone Lysine Methyltransferase G9a, tyrosyl-DNA phosphodiesterase 1 (TDP1), and the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). These bioactivities suggest that Cyclopiazonic acid has potential applications in therapeutic interventions for a variety of conditions..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Cyclopiazonic acid (CPA) is a neurotoxic secondary metabolite (SM) made by A. flavus. Cyclopiazonic acid (CPA) is an endoplasmic reticulum calcium ATPase (Ca2+ATPase; SERCA)nanomolar inhibitor and a potent inducer of cell death in plants.
别名	环匹阿尼酸, 环二氮酸

化学信息

分子量	336.38
分子式	C₂₀H₂₀N₂O₃
CAS No.	18172-33-3
Smiles	[H][C@@]12Cc3cccc4[nH]cc(c34)[C@]1([H])[C@]1([H])N(C(O)=C(C(C)=O)C1=O)C2(C)C
密度	1.42g/cm3
颜色	Yellow
物理性状	Solid

储存&溶解度

存储

store at low temperature,keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 100 mg/mL (297.28 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (11.89 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9728 mL	14.8641 mL	29.7283 mL	148.6414 mL
5 mM	0.5946 mL	2.9728 mL	5.9457 mL	29.7283 mL
10 mM	0.2973 mL	1.4864 mL	2.9728 mL	14.8641 mL
20 mM	0.1486 mL	0.7432 mL	1.4864 mL	7.4321 mL
50 mM	0.0595 mL	0.2973 mL	0.5946 mL	2.9728 mL
100 mM	0.0297 mL	0.1486 mL	0.2973 mL	1.4864 mL