Chloroxine

Name: Chloroxine
Brand: TargetMol
SKU: T0500
Price: 129 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.75%

货号 T0500Cas号 773-76-2

别名 氯喔星, Capitrol

Chloroxine (Capitrol) 是重要的 8-羟基喹啉衍生物之一，有抗细菌，抗真菌，抗原生动物和抗阿米巴虫活性，可研究肠道阿米巴病，还可研究头皮屑和头皮脂溢性皮炎。

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Chloroxine

一键复制产品信息

很棒

纯度: 99.75%

货号 T0500 别名 氯喔星, CapitrolCas号 773-76-2

规格	价格	库存
500 mg	¥ 129	现货
1 g	¥ 163	现货
2 g	¥ 186	现货
5 g	¥ 222	现货
10 g	¥ 313	现货
1 mL x 10 mM (in DMSO)	¥ 179	现货

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产品介绍

Chloroxine AI Summary

Chloroxine exhibits a diverse range of bioactivities targeting multiple cellular functions and pathways. It has cytotoxic effects on Streptococcus and SK(-)GAS group A Streptococcus with EC50 values of 258.0 nM and 3306.0 nM, respectively. The compound shows significant inhibitory activity against HIV-1 integrase, various lipoxygenase enzymes, and several human enzymes including HDAC6, JMJD2E, and NDM-1, VIM-1, and IMP-1 enzymatic families. It also inhibits mitochondrial division, SMN2 splice variant expression, Tau fibril formation, and more, with potency values ranging from 3981.1 nM to 70794.6 nM. In antiviral studies, Chloroxine inhibits SARS-CoV-2 induced cytotoxicity and papain-like protease with varied efficacy, showing an IC50 value of 7240.0 nM for the latter. It exhibits anti-fungal activity against Candida albicans and Cryptococcus neoformans with MIC values of 1250.0 nM and 2500.0 nM, respectively, but does not significantly affect several bacterial strains at concentrations over 10000.0 nM. The compound demonstrates binding affinities and inhibitory activities against MMP-14, MMP-9, and MMP-13, with IC50 values of 25600.0 nM, 15900.0 nM, and 19600.0 nM, respectively. Furthermore, Chloroxine inhibits the uptake of sodium fluorescein in OATP1B1 and OATP1B3-transfected CHO cells, and activates human PXR in HepG2 cells, leading to an efficacy of 107.9% compared to rifampicin. It also shows high metabolic stability in human and Sprague-Dawley rat plasma with a half-life of 67.7 hr and 18.6 hr, respectively, but a shorter half-life in liver microsomes. The compound's solubility varies with pH, being more soluble at pH 1. Overall, Chloroxine is notable for its multifaceted bioactivities, including significant antiviral, enzyme inhibitory, and anti-fungal properties, making it a promising candidate for further biomedical research..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Chloroxine (Capitrol) is a synthetic quinoline derivative with antibacterial activity. Although the mechanism of action is not fully understood, topical administration of chloroxine diminishes mitotic activity in the epidermis, thereby reducing excessive scaling associated with dandruff or seborrheic dermatitis of the scalp, including psoriasis and eczema.
别名	氯喔星, Capitrol

化学信息

分子量	214.05
分子式	C₉H₅Cl₂NO
CAS No.	773-76-2
Smiles	OC1=C(Cl)C=C(Cl)C2=CC=CN=C12
密度	1.3320 g/cm3 (Estimated)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 6.25 mg/mL (29.2 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.6718 mL	23.3590 mL	46.7181 mL	233.5903 mL
5 mM	0.9344 mL	4.6718 mL	9.3436 mL	46.7181 mL
10 mM	0.4672 mL	2.3359 mL	4.6718 mL	23.3590 mL
20 mM	0.2336 mL	1.1680 mL	2.3359 mL	11.6795 mL