Name: MSI-1436
Brand: TargetMol
SKU: T12116
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

25 mg

¥ 18,000

10-14周

50 mg

¥ 25,800

10-14周

100 mg

¥ 31,500

10-14周

生物活性

产品描述	MSI-1436 is a selective, non-competitive the enzyme protein-tyrosine phosphatase 1B (PTB1B)inhibitor(IC50 of appr 1 μM)
靶点活性	TCPTP:224 μM , PTB1B:1 μM
体外活性	Trodusquemine significantly enhanced insulin-stimulated tyrosine phosphorylation of insulin receptor (IR) beta and STAT3, direct targets of PTP1B, in HepG2 cells in vitro and/or hypothalamic tissue[1].
体内活性	Trodusquemine (MSI-1436) causes rapid and reversible weight loss in genetic models of obesity.?Trodusquemine suppressed appetite, reduced body weight (BW) in a fat-specific manner, and improved plasma insulin and leptin levels in mice[1].
别名	Trodusquemine, Aminosterol-1436

化学信息

分子量	685.06
分子式	C₃₇H₇₂N₄O₅S
CAS No.	186139-09-3
Smiles	O[C@H]1[C@@]2([C@@]([C@]3(C)[C@@](C1)(C[C@@H](NCCCNCCCCNCCCN)CC3)[H])(CC[C@@]4(C)[C@]2(CC[C@@]4([C@@H](CC[C@@H](OS(=O)(=O)O)[C@H](C)C)C)[H])[H])[H])[H]
密度	1.12 g/cm3 (Predicted)

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准

MSI-1436