MAGL-IN-5

Name: MAGL-IN-5
Brand: TargetMol
SKU: T9967
Price: 170 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.73%

货号 T9967Cas号 359714-55-9

MAGL-IN-5 是一种非选择性脂肪酶抑制剂。

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MAGL-IN-5

一键复制产品信息

很棒

纯度: 99.73%

货号 T9967Cas号 359714-55-9

MAGL-IN-5 是一种非选择性脂肪酶抑制剂。

规格	价格	库存
1 mg	¥ 170	现货
2 mg	¥ 239	现货
5 mg	¥ 395	现货
10 mg	¥ 598	现货
25 mg	¥ 1,290	现货
50 mg	¥ 2,020	现货
100 mg	¥ 2,890	现货
200 mg	¥ 4,030	现货
1 mL x 10 mM (in DMSO)	¥ 310	现货

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纯度: 99.73%

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产品介绍

MAGL-IN-5 AI Summary

MAGL-IN-5 demonstrates potent inhibitory activity against both human recombinant FAAH (Fatty Acid Amide Hydrolase) and MAGL (Monoacylglycerol Lipase). Specifically, it exhibits an IC50 value of 77.62 nM for FAAH inhibition and an IC50 value of 20.42 nM for MAGL inhibition, with a selectivity ratio favoring MAGL by approximately 3.0. The compound's bioactivity is characterized by its variable potency depending on assay conditions, with IC50 values for MAGL inhibition ranging from 9.0 nM to 480.0 nM and for FAAH inhibition from 14.0 nM to 1,300.0 nM. In addition to its enzyme inhibitory effects, MAGL-IN-5 shows antiproliferative activity against multiple human cancer cell lines, where IC50 values range from 34,000 nM to over 200,000 nM after 96 hours of exposure. The compound has potential therapeutic applications in modulating endocannabinoid signaling pathways due to its high affinity and selective enzyme inhibition..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	MAGL-IN-5 is a non-selective lipase inhibitor.

化学信息

分子量	355.34
分子式	C₁₈H₁₇N₃O₅
CAS No.	359714-55-9
Smiles	COc1nn(-c2ccc(NC(=O)OCc3ccccc3)c(C)c2)c(=O)o1
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 95 mg/mL (267.35 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (9.29 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8142 mL	14.0710 mL	28.1421 mL	140.7103 mL
5 mM	0.5628 mL	2.8142 mL	5.6284 mL	28.1421 mL
10 mM	0.2814 mL	1.4071 mL	2.8142 mL	14.0710 mL
20 mM	0.1407 mL	0.7036 mL	1.4071 mL	7.0355 mL
50 mM	0.0563 mL	0.2814 mL	0.5628 mL	2.8142 mL
100 mM	0.0281 mL	0.1407 mL	0.2814 mL	1.4071 mL