Guanosine 5'-diphosphate

Name: Guanosine 5'-diphosphate
Brand: TargetMol
SKU: T7210
Rating: 4.5 (1 reviews)

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纯度: 99.52%

货号 T7210Cas号 146-91-8

别名 鸟苷-5ˊ-二磷酸, GDP

Guanosine 5'-diphosphate (GDP) 是核苷二磷酸，是潜在的铁动员剂，能够阻断铁调素-铁转运蛋白相互作用并调节白细胞介素-6 (IL-6)/stat-3 途径。

Guanosine 5'-diphosphate

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纯度: 99.52%

货号 T7210 别名 鸟苷-5ˊ-二磷酸, GDPCas号 146-91-8

Guanosine 5'-diphosphate (GDP) 是核苷二磷酸，是潜在的铁动员剂，能够阻断铁调素-铁转运蛋白相互作用并调节白细胞介素-6 (IL-6)/stat-3 途径。

规格	价格	库存
5 mg	¥ 348	5日内发货
10 mg	¥ 497	5日内发货
25 mg	¥ 732	5日内发货
50 mg	¥ 867	5日内发货
100 mg	¥ 1,590	5日内发货
200 mg	¥ 2,390	5日内发货
500 mg	¥ 3,970	5日内发货

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产品介绍

Guanosine 5'-diphosphate AI Summary

Guanosine 5'-diphosphate demonstrates a broad spectrum of bioactivities across multiple targets and assays. It inhibits fucosyltransferase enzymes, including Fucosyltransferase 4 alpha 1,3 with an IC50 value of 5000.0 nM, Fucosyltransferase (FucT V) with an IC50 value of 67000.0 nM, and human recombinant alpha1,3-fucosyltransferase 9 with a Ki of 77900.0 nM and an IC50 of 59000.0 nM. Moreover, it inhibits Helicobacter pylori recombinant alpha1,3-fucosyltransferase with an inhibition percentage of up to 75.0%. In addition, it has a binding affinity to Escherichia coli KPR (Kd of 373000.0 nM) and shows an inhibition of 8.5% on Trypanosoma brucei brucei DPMS at 1 mM. In terms of receptor activity, Guanosine 5'-diphosphate acts as an agonist at human recombinant P2Y2, P2Y4, and P2Y6 receptors, with respective EC50 values of 54.0, 90.0, and 45000.0 nM, mediated by PLC and [3H]IP production. It also induces phagocytosis in Wistar rat microglia, showing 49.7% activity at 100 uM over 20 minutes. Furthermore, the compound exhibits bioactivity in several other assays: it enhances SMN2 splice variant expression (potency of 14125.4 nM), inhibits Aldehyde Dehydrogenase 1 (ALDH1A1) with a potency of 2818.4 nM, and inhibits Regulator of G Protein Signaling (RGS) 4 with a potency of 597.3 nM. It also shows binding affinity to Mg2+ ions as determined by 31P NMR analysis with activities of 0.5 and 2.0 equiv, and interacts with various mutants of Rab7 GTPase and wild-type Rab7 with Kd values ranging from 25.83 nM to 109.2 nM, suggesting potential modulatory effects on Rab7 GTPase functions..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Guanosine 5'-diphosphate (GDP) as Potential Iron Mobilizer, Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway.
别名	鸟苷-5ˊ-二磷酸, GDP

化学信息

分子量	443.2
分子式	C₁₀H₁₅N₅O₁₁P₂
CAS No.	146-91-8
Smiles	O[C@H]1[C@H](N2C3=C(N=C2)C(=O)N=C(N)N3)O[C@H](COP(OP(=O)(O)O)(=O)O)[C@H]1O
密度	2.63 g/cm3 (Predicted)
颜色	White
物理性状	solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: 50 mg/mL (112.82 mM), Sonication is recommended.

溶液配制表

H2O

	1mg	5mg	10mg	50mg
1 mM	2.2563 mL	11.2816 mL	22.5632 mL	112.8159 mL
5 mM	0.4513 mL	2.2563 mL	4.5126 mL	22.5632 mL
10 mM	0.2256 mL	1.1282 mL	2.2563 mL	11.2816 mL
20 mM	0.1128 mL	0.5641 mL	1.1282 mL	5.6408 mL
50 mM	0.0451 mL	0.2256 mL	0.4513 mL	2.2563 mL
100 mM	0.0226 mL	0.1128 mL	0.2256 mL	1.1282 mL