Acetohexamide

Name: Acetohexamide
Brand: TargetMol
SKU: T0816
Price: 148 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.85%

货号 T0816Cas号 968-81-0

别名 醋磺己脲, 醋磺环已脲, Gamadiabet, Dymelor, Acetohexamid

Acetohexamide (Acetohexamid) 是磺脲类试剂，可刺激胰腺分泌胰岛素，能够用于 2 型糖尿病的相关研究。

Acetohexamide

一键复制产品信息

很棒

纯度: 99.85%

货号 T0816 别名 醋磺己脲, 醋磺环已脲, Gamadiabet, Dymelor, AcetohexamidCas号 968-81-0

Acetohexamide (Acetohexamid) 是磺脲类试剂，可刺激胰腺分泌胰岛素，能够用于 2 型糖尿病的相关研究。

规格	价格	库存
25 mg	¥ 148	现货
50 mg	¥ 197	现货
100 mg	¥ 335	现货
1 mL x 10 mM (in DMSO)	¥ 277	现货

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纯度: 99.85%

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COA HNMR HPLC 产品操作手册

产品介绍

Acetohexamide AI Summary

Acetohexamide exhibits a wide array of bioactivities and interactions across various biological targets. It has shown a binding affinity to beta cyclodextrin with a log Ks value of 2.94 and displays multiple potencies: inhibiting the thyroid hormone receptor interaction (2.5 nM), activating the thyroid stimulating hormone receptor (6.3 nM), inhibiting ALDH1A1 (39810.7 nM), and Bloom's syndrome helicase (2.8 nM). It also demonstrates inhibitory activity against histone lysine methyltransferase G9a (2667.9 nM and 3162.3 nM), functions as an antagonist of farnesoid X receptor signaling (2.2 nM), and inhibits Mammalian Selenoprotein Thioredoxin Reductase 1 (1258.9 nM). Acetohexamide exhibits a plasma protein binding of 75.0%, a log P value of 2.4, and a 1-octanol-water distribution coefficient (log D) of -0.3 at pH 7.4 and 1.3 at pH 5.5. It has a moderate hydrophilic nature with a LogD7.4 value of -0.49. From a toxicity perspective, Acetohexamide displays moderate cytolytic liver toxicity, as indicated by increased ALT or AST levels, and shows potential for inducing drug-induced liver injury in the Drug Induced Liver Injury Prediction System (DILIps). The compound has antiviral activities, including activity against SARS-CoV-2. It inhibits virus-induced cytotoxicity in VERO-6 cells, with limited effectiveness indicated by an inhibition index of 0.1115 in Vero E6 cells and an IC50 greater than 20,000 nM in other assays. It shows variable inhibition percentages of SARS-CoV-2 3CL-Pro protease at 20 µM (15.64% and 9.27%) and inhibition of cytotoxicity in Caco-2 cells and HRCE cells. Additionally, it has shown 100.0% inhibition of CHIKV replication in hamster BHK-21 cells at 20 µM concentration. In terms of receptor interactions, Acetohexamide has binding affinities towards various receptors such as ADRB2, OPRM1, and HRH2, and displays agonist or antagonist activities in receptors like CHRM2 and HTR1A. It also inhibits enzymes such as PTGS2 and MAOA. Overall, Acetohexamide demonstrates diverse bioactivities and interactions, making it a candidate for multiple pharmacological applications, although its potential hepatotoxic effects require careful consideration..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Acetohexamide (Acetohexamid) is an intermediate-acting, first-generation sulfonylurea with hypoglycemic activity. It inhibits sulfonylurea receptor 1 (SUR1) linked to the inwardly rectifying potassium channel (KIR6.2) with Ki values of 22.9 and 14.2 μM in HEK293 cells transfected with the human receptor and in rat brain, respectively. Acetohexamide is metabolized in the liver to its active metabolite hydroxyhexamide.
靶点活性	KIR6.2:14.2 µM(Ki), SUR1:22.9 µM(Ki)
别名	醋磺己脲, 醋磺环已脲, Gamadiabet, Dymelor, Acetohexamid

化学信息

分子量	324.40
分子式	C₁₅H₂₀N₂O₄S
CAS No.	968-81-0
Smiles	CC(=O)c1ccc(cc1)S(=O)(=O)NC(=O)NC1CCCCC1
密度	1.3g/cm3
颜色	White
物理性状	solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 30 mg/mL (92.48 mM), Sonication is recommended.

体内实验配方

10% DMSO+90% Corn Oil: 2 mg/mL (6.17 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0826 mL	15.4131 mL	30.8261 mL	154.1307 mL
5 mM	0.6165 mL	3.0826 mL	6.1652 mL	30.8261 mL
10 mM	0.3083 mL	1.5413 mL	3.0826 mL	15.4131 mL
20 mM	0.1541 mL	0.7707 mL	1.5413 mL	7.7065 mL
50 mM	0.0617 mL	0.3083 mL	0.6165 mL	3.0826 mL