Iopanoic acid

Name: Iopanoic acid
Brand: TargetMol
SKU: T0960
Price: 129 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 97.06%

货号 T0960Cas号 96-83-3

别名 碘番酸, Iodopanoic acid, Acidum iopanoicum

Iopanoic acid 是一种碘造影剂，也是一种 5'-Deiodinase 抑制剂。

Iopanoic acid

一键复制产品信息

很棒

纯度: 97.06%

货号 T0960 别名 碘番酸, Iodopanoic acid, Acidum iopanoicumCas号 96-83-3

Iopanoic acid 是一种碘造影剂，也是一种 5'-Deiodinase 抑制剂。

规格	价格	库存
25 mg	¥ 169	现货
50 mg	¥ 233	现货
100 mg	¥ 328	现货
500 mg	¥ 783	现货
1 mL x 10 mM (in DMSO)	¥ 129	现货

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纯度: 97.06%

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COA HNMR LCMS 产品操作手册

产品介绍

Iopanoic acid AI Summary

Iopanoic acid shows rapid distribution in various organs of female rats following intravenous administration, with detectable percentages in blood, heart, kidney, lung, and liver at both 5 and 30 minutes post-administration. Analysis through polyacrylamide gel electrophoresis indicates its presence in different plasma components such as low-density lipoprotein, high-density lipoprotein, and albumin at multiple time points. Bioactivity studies reveal that Iopanoic acid inhibits enzymes including Histone Lysine Methyltransferase G9a, ELG1-dependent DNA repair, and human tyrosyl-DNA phosphodiesterase 1 (TDP1), among others. It also exhibits antagonistic activity against cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2) and blocks Ebola Virus entry under different screening conditions. Additionally, it inhibits sodium fluorescein uptake in OATP1B3- and OATP1B1-transfected CHO cells at a 10 µM concentration. Toxicologically, Iopanoic acid induces moderate to acute liver toxicity demonstrated by elevated clinical-chemistry markers (ALT and AST). However, there are no indications of chronic liver diseases or related conditions such as cirrhosis or cancer. In terms of antiviral activity, Iopanoic acid inhibits SARS-CoV-2 induced cytotoxicity in VERO-6 cells and Caco-2 cells, although with relatively high IC50 values exceeding 20,000 nM. It also exhibits minimal inhibition of the SARS-CoV-2 3CL-Pro protease. Furthermore, Iopanoic acid shows inhibitory potential on the human HDAC6 enzyme and antagonistic activity towards human TBXA2R and CHRM1 receptors, with agonist activity at human ADRA1A receptor. While it demonstrates binding to various receptors and enzymes, significant bioactivity is largely absent at target sites tested, as indicated by AC50 values above 30,000 nM for most targets except a few..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Iopanoic acid is an iodine contrast agent and a 5'-Deiodinase inhibitor.
别名	碘番酸, Iodopanoic acid, Acidum iopanoicum

化学信息

分子量	570.93
分子式	C₁₁H₁₂I₃NO₂
CAS No.	96-83-3
Smiles	CCC(Cc1c(I)cc(I)c(N)c1I)C(O)=O
密度	2.426g/cm3
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (96.33 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.5 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7515 mL	8.7576 mL	17.5153 mL	87.5764 mL
5 mM	0.3503 mL	1.7515 mL	3.5031 mL	17.5153 mL
10 mM	0.1752 mL	0.8758 mL	1.7515 mL	8.7576 mL
20 mM	0.0876 mL	0.4379 mL	0.8758 mL	4.3788 mL
50 mM	0.0350 mL	0.1752 mL	0.3503 mL	1.7515 mL