Primordazine B is a small molecule that selectively ablates Primordial Germ Cells (PGCs). It functions by specifically inhibiting a process known as Poly(A)-tail Independent Non-canonical Translation (PAINT), without interfering with typical Poly(A) tail-dependent translation (PAT). Primordazine B serves as a valuable tool for investigating translational control mechanisms in specific physiological or pathological contexts, such as gene expression regulation during cell dormancy, viral infection, or stress conditions.