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W-84 dibromide

Name: W-84 dibromide
Brand: TargetMol
SKU: T23524
Price: 197 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 95.56%

货号 T23524Cas号 21093-51-6

别名 HDMPPA

W-84 dibromide (HDMPPA) 是 M2胆碱受体的强变构调节剂，是一种非竞争性毒蕈碱乙酰胆碱受体拮抗剂，具有变构效应。它联合阿托品时，可有效地防止有机磷中毒。它阻碍 [3H]N-甲基东莨菪碱解离，能稳定胆碱能拮抗剂-受体复合物。

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W-84 dibromide

一键复制产品信息

很棒

纯度: 95.56%

货号 T23524 别名 HDMPPACas号 21093-51-6

规格	价格	库存
1 mg	¥ 197	现货
2 mg	¥ 283	现货
5 mg	¥ 473	现货
10 mg	¥ 738	现货
25 mg	¥ 1,590	现货
50 mg	¥ 2,380	现货
100 mg	¥ 3,410	现货
200 mg	¥ 4,730	现货

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COA HNMR LCMS 产品操作手册

产品介绍

W-84 dibromide AI Summary

W-84 dibromide exhibits binding affinity and bioactivity towards the muscarinic acetylcholine receptor M2, particularly in porcine heart ventricle and cardiac tissues. It demonstrates a binding affinity characterized by a -logKa of 6.19 and cooperativity with a pAlpha of -0.47. The compound has a pAlphaKa value of 5.73 for [3H]NMS-occupied muscarinic acetylcholine receptors, indicating moderate binding affinity, and it shows an effective concentration (EC50) of approximately 1348.96 nM to inhibit [3H]NMS dissociation from the receptor. Furthermore, W-84 dibromide exhibits allosteric potency with an EC50 value of around 1440 nM and a half-life of 18.0 hours in the context of dissociating radioligand [3H]N-methylscopolamine. The compound is moderately lipophilic, with a logP value of 1.46. It demonstrates inhibition of [3H]-N-methyl-scopolamine dissociation from porcine cardiac M2-receptors with an EC50 value of approximately 1412.54 nM. Its binding affinity varies across different experiments with Ki values ranging from 31.62 nM to 1071.52 nM. The bioactivity of W-84 dibromide includes displacement assays targeting the human muscarinic M2 receptor expressed in CHO-K9 cells, with competition binding assay Kd values ranging from 148 nM to 457 nM and Ki values in flow cytometry assays from approximately 1412 nM to 851.14 nM. Overall, W-84 dibromide is a potential modulator of the muscarinic acetylcholine receptor M2, showing various levels of affinity and inhibitory effects in different assay conditions and receptor subtypes..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	W-84 dibromide (HDMPPA) is a M2-receptor selective modulator.
别名	HDMPPA

化学信息

分子量	708.52
分子式	C₃₂H₄₄Br₂N₄O₄
CAS No.	21093-51-6
Smiles	[Br-].[Br-].C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 7.11 mg/mL (10.04 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4114 mL	7.0570 mL	14.1139 mL	70.5696 mL
5 mM	0.2823 mL	1.4114 mL	2.8228 mL	14.1139 mL
10 mM	0.1411 mL	0.7057 mL	1.4114 mL	7.0570 mL

计算器

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体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。