Name: NU6300
Brand: TargetMol
SKU: T16360
Rating: 4.5 (1 reviews)

NU6300

很棒

产品编号 T16360Cas号 2070015-09-5

别名 NU 6300

NU6300是一种共价的CDK2抑制剂,具有不可逆和ATP竞争性的特点，IC50=0.16 μM，抑制Rb(retinoblastoma tumor suppressor protein)磷酸化，可用于研究真核细胞周期和转录相。NU6300还是一种GSDMD(Gasdermin D)抑制剂，能够阻止半胱氨酸-191的裂解和棕榈酰化,抑制NLRP3的早期步骤，可用于结肠炎和脓毒症。

规格

价格

库存

数量

1 mg

¥ 2,970

8-10周

5 mg

¥ 7,070

In stock

1 mL x 10 mM (in DMSO)

¥ 7,830

5日内发货

产品介绍

生物活性

产品描述	NU6300 is a covalent CDK2 inhibitor exhibiting irreversible and ATP-competitive properties with an IC50 of 0.16 μM. It inhibits Rb (retinoblastoma tumour suppressor protein) phosphorylation and is suitable for research into eukaryotic cell cycle and transcription-related studies. NU6300 also functions as a GSDMD (Gasdermin D) inhibitor, blocking cleavage and palmitoylation of cysteine-191 to suppress early NLRP3 activation pathways, making it applicable for colitis and sepsis research.
靶点活性	CDK2:0.16 μM
体外活性	NU6300对细胞焦亡表现出剂量依赖性挽救作用，在THP-1细胞和骨髓来源的巨噬细胞（BMDM）中的一半最大抑制浓度（IC50）值分别为0.89和0.93μM。[1]
别名	NU 6300

化学信息

分子量	413.49
分子式	C₂₀H₂₃N₅O₃S
CAS No.	2070015-09-5
Smiles	C=CS(=O)(=O)c1ccc(Nc2nc(OCC3CCCCC3)c3nc[nH]c3n2)cc1
密度	1.344 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 80 mg/mL (193.48 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4184 mL	12.0922 mL	24.1844 mL	120.9219 mL
5 mM	0.4837 mL	2.4184 mL	4.8369 mL	24.1844 mL
10 mM	0.2418 mL	1.2092 mL	2.4184 mL	12.0922 mL
20 mM	0.1209 mL	0.6046 mL	1.2092 mL	6.0461 mL
50 mM	0.0484 mL	0.2418 mL	0.4837 mL	2.4184 mL
100 mM	0.0242 mL	0.1209 mL	0.2418 mL	1.2092 mL

体内实验配液计算器