规格

价格

库存

数量

1 mg

¥ 959

现货

5 mg

¥ 1,980

现货

10 mg

¥ 3,290

现货

25 mg

¥ 5,280

现货

50 mg

¥ 7,260

现货

100 mg

¥ 9,790

现货

200 mg

¥ 13,200

现货

1 mL x 10 mM (in DMSO)

¥ 2,720

现货

生物活性

产品描述	Lotilaner is a parasiticide. It is used as a potent non-competitive antagonist of insects GABACl receptors (IC50 of 23.84 nM for Drosophila melanogaster GABA receptor). It also has no effect on a dog GABAA receptor.
靶点活性	GABA:36.79 nM(Rm), GABA:52.40 nM(Ls-GABA1), GABA:38.25 nM(DmR2), GABA:23.84 nM(DmS)
体外活性	Lotilaner针对Drosophila melanogaster dieldrin/fipronil-resistant forms (DmR2)、Lepeophtheirus salmonis (Ls) 以及Rhipicephalus microplus (Rm) 的GABACl受体表现出了IC50值分别为38.25 ± 3.75、52.40 ± 4.54和36.79 ± 4.39 nM。
别名	洛替拉纳

化学信息

分子量	596.76
分子式	C₂₀H₁₄Cl₃F₆N₃O₃S
CAS No.	1369852-71-0
Smiles	Cc1cc(sc1C(=O)NCC(=O)NCC(F)(F)F)C1=NO[C@@](C1)(c1cc(Cl)c(Cl)c(Cl)c1)C(F)(F)F
密度	1.66 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: ≥ 150 mg/mL (251.36 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.35 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO