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Acriflavine Hydrochloride

Name: Acriflavine Hydrochloride
Brand: TargetMol
SKU: T19832
Price: 195 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 盐酸吖啶黄, Acriflavine HCl

货号 T19832Cas号 8063-24-9 一键复制产品信息纯度: 99.8%

很棒

Acriflavine Hydrochloride (Acriflavine HCl) 是一种 HIF-1α 抑制剂。它通过靶向 HIF-1α 介导的途径并在体外和体内降低 PGK1、VEGF 和 HIF-1α 的水平发挥作用。

Acriflavine Hydrochloride

一键复制产品信息

很棒

纯度: 99.8%

货号 T19832Cas号 8063-24-9

别名 盐酸吖啶黄, Acriflavine HCl

Acriflavine Hydrochloride (Acriflavine HCl) 是一种 HIF-1α 抑制剂。它通过靶向 HIF-1α 介导的途径并在体外和体内降低 PGK1、VEGF 和 HIF-1α 的水平发挥作用。

规格	价格	库存	数量
500 mg	¥ 289	现货
1 mL x 10 mM (in DMSO)	¥ 195	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.8%

颜色: 红色

性状: Solid

资源下载: COA HNMR LCMS产品操作手册

产品介绍

Acriflavine Hydrochloride AI Summary

Acriflavine Hydrochloride is a multifaceted bioactive molecule with a partition coefficient (logD7.4) of 1.6, indicating moderate lipophilicity. It has demonstrated significant trypanocidal activity against Trypanosoma brucei, with increasing efficacy under higher concentrations and light exposure. Notably, it impacts the cross resistance of CHO cells resistant to colchicine (CHRC5) with a log CR value of 0.84. The compound exhibits strong antimicrobial properties against a variety of bacterial strains, including Escherichia coli, Enterobacter cloacae, methicillin-resistant Staphylococcus aureus (MRSA), and Burkholderia pseudomallei. Its Minimum Inhibitory Concentrations (MIC) against these strains vary widely, reflecting differential efficacy based on specific genetic and resistance profiles. For example, MICs against multidrug-resistant E. coli with mutated GyrA gene exceed 128.0 µg/mL, while against other strains, MICs range from 2.0 to 4.0 µg/mL. The compound also affects the AcrAB-TolC efflux pump system, with an MIC of 400.0 µg/mL in Escherichia coli, and demonstrates efficacy against MRSA, with MIC50 at 12.5 µg/mL and MIC90 at 50.0 µg/mL. Furthermore, Acriflavine Hydrochloride shows potent antiviral activity, including a 74.97% inhibition of SARS-CoV-2 induced cytotoxicity in Caco-2 cells at 10 µM, and a 98.59% inhibition of SARS-CoV-2 3CL-Pro protease at 20 µM. It also inhibits HIF-1 dimerization in HEK293 cells with an IC50 of 1000 nM. In addition to its antimicrobial and antiviral activities, Acriflavine Hydrochloride impacts protein interactions and enzymatic activities, including Menin-MLL, BRCT-Phosphoprotein, Caspase-1, and Cytochrome P450 3A4. It also influences cellular responses such as ER Stress Response and DNA re-replication and exhibits antagonistic effects on proteins like MgcRacGAP. Overall, Acriflavine Hydrochloride is a versatile compound with significant potential in antimicrobial, antiviral, and cellular bioactivity modulation applications..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Acriflavine Hydrochloride (Acriflavine HCl) is a HIF-1α inhibitor. It acts by targeting HIF-1α-mediated pathways and decreasing the level of PGK1, VEGF, and HIF-1α in vitro and in vivo.
别名	盐酸吖啶黄, Acriflavine HCl

化学信息

分子量	259.73
分子式	C₁₄H₁₄ClN₃
CAS No.	8063-24-9
Smiles	C[N+]1=C2C=C(N)C=CC2=CC3=C1C=C(N)C=C3.[Cl-]
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 41.67 mg/mL (160.44 mM), Sonication is recommended.

体内实验配方

10% DMSO+90% Saline: 4.17 mg/mL (16.06 mM), Solution.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8502 mL	19.2508 mL	38.5015 mL	192.5076 mL
5 mM	0.7700 mL	3.8502 mL	7.7003 mL	38.5015 mL
10 mM	0.3850 mL	1.9251 mL	3.8502 mL	19.2508 mL
20 mM	0.1925 mL	0.9625 mL	1.9251 mL	9.6254 mL
50 mM	0.0770 mL	0.3850 mL	0.7700 mL	3.8502 mL
100 mM	0.0385 mL	0.1925 mL	0.3850 mL	1.9251 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

HIF-1α Acriflavine Hydrochloride

Acriflavine Hydrochloride

Acriflavine Hydrochloride