规格

价格

库存

数量

1 mg

¥ 678

现货

2 mg

¥ 995

现货

5 mg

¥ 1,620

现货

10 mg

¥ 2,860

现货

25 mg

¥ 4,760

现货

50 mg

¥ 6,780

现货

100 mg

¥ 9,180

现货

1 mL x 10 mM (in DMSO)

¥ 1,980

现货

生物活性

产品描述	Mizagliflozin is an orally active, selective SGLT1 inhibitor with a Ki value of 27 nM for human SGLT1. Mizagliflozin is 303 times more selective for SGLT1 than for SGLT2. Mizagliflozin is an anti-diabetic drug that can improve postprandial blood sugar fluctuations and may have the potential to improve chronic constipation.
靶点活性	SGLT2 (human):8170 nM(ki), SGLT1 (human):(ki)27 nM
体内活性	方法：Mizagliflozin (GSK-1614235 free base)（0.3 mg/kg，静脉给药）和口服给药（3 mg/kg，口服给药）给大鼠，研究其药代动力学和代谢物谱。结果：Mizagliflozin在大鼠中给药方式不同，半衰期也不同（分别为0.23和1.14小时）；绝对生物利用度仅为0.02%；口服给药Mizagliflozin后主要在肠道中代谢为其苷元KP232。[2]
别名	KGA-3235 free base, GSK-1614235 free base, DSP-3235 free base

化学信息

分子量	564.67
分子式	C₂₈H₄₄N₄O₈
CAS No.	666843-10-3
Smiles	CC(C)c1[nH]nc(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1Cc1ccc(OCCCNCC(C)(C)C(N)=O)cc1C
密度	1.274 g/cm3 (Predicted)
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

Methanol: 250 mg/mL (442.74 mM), Sonication is recommended.

DMSO: 100 mg/mL (177.09 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (7.08 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO/Methanol